Linagliptin is indicated in the treatment of type 2 diabetes mellitus to improve glycaemic control in adults.

• As monotherapy: in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance or contraindicated due to renal impairment.
• As combination therapy: in combination with metformin when diet and exercise plus metformin alone do not provide adequate glycaemic control in combination with a sulphonylurea and metformin when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Linagliptin is indicated to improve glycemic control in patients with type 2 diabetes mellitus. Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon like peptide-1) and GIP (glucose dependent insulinotropic polypeptide). Thus, Linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin from pancreatic beta (β) cells in a glucose-dependent manner and decreasing the secretion of glucagon from pancreatic alpha (α) cells in the circulation.

Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly. When used in combination with a sulfonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.

Patients with renal impairment: No dose adjustment required. Linagliptin can be taken with or without a meal at any time of the day.

Linagliptin is a weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4, but does not inhibit other CYP isozymes. The risk for clinically meaningful interactions by other medicinal products on linagliptin is low and in clinical studies linagliptin had no clinically relevant effect on the pharmacokinetics of metformin, glyburide, simvastatin, warfarin, digoxin or oral contraceptives.

Hypersensitivity to the active substance or to any of the excipients.

There may be hypoglycaemia, nasopharyngitis, cough and pancreatitis in combination with metformin and sulfonylurea.

Pregnancy category B. There are no adequate and well controlled studies in pregnant women. So, Linagliptin tablets should be used during pregnancy only if clearly needed. It is not known whether Linagliptin passes into breast milk or not.

Hypersensitivity to the active substance or to any of the excipients.

Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Keep in a dry place away from light and heat. Keep out of the reach of children.

Molecular Formula : C25H28N8O2

Chemical Structure : 

What is Linagliptin?

Linagliptin is an inhibitor of DPP-4 enzyme.

What is Linagliptin used for?

Linagliptin is used for the treatment of type 2 diabetes mellitus to improve glycaemic control in adults.

How long do I need to use Linagliptin before I see improvement in my condition?

Linagliptin is to be taken till the time you see an improvement in your health conditions.

At what frequency do I need to use Linagliptin?

Linagliptin should be taken in the dosage as prescribed by the doctor.

Should I use Linagliptin empty stomach, before food or after food?

Linagliptin should be taken after food in a prescribed dosage.

What are the instructions for the storage and disposal of Linagliptin?

Linagliptin should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

Quick Tips

• Linagliptin should be taken at the same time every day since this helps you remember to take it.
• Linagliptin may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
• Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
• Be careful while driving or operating machinery until you know how Linagliptin affects you.
• Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting.