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Diclofenac Sodium

Indications

Diclofenac Sodium is indicated in-

Rheumatology: Inflammatory and degenerative forms of rheumatism, chronic involutive, polyarthritis, ankylosing spondylarthritis, osteoarthritis, spondylarthroses, acute gout, peri-articular rheumatic disorders.

Surgery and Traumatology: Sprain, bruises, dislocations, fractures, softtissue injuries, surgical interventions.

Obstetrics and Gynecology: Primary dysmenorrhoea, episiotomy, adnexitis, endometritis, parametritis, salpingitis, and mastitis.

Otorhinolaryngology: As pre-operative medication for the prevention of pain, inflammation, and swelling.

Dentistry: Post-operative and post-traumatic pain, inflammation, and swelling.

Other indications: For the prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract, renal and biliary colic.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Dilofenac Sodium is a potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It has also some uricosuric effect. Diclofenac exerts its effect by inhibiting prostaglandin biosynthesis which plays a major role in causing inflammation, pain and fever. Diclofenac is rapidly and completely absorbed from the gastro-intestinal tract when taken with or after meal. Peak plasma concentrations are reached within an average of 2 hours after ingestion of it. At therapeutic concentrations, it is 99.7% bound to plasma proteins. Diclofenac is metabolized in the liver and undergoes first pass metabolism.

Dosage & Administration

Diclofenac FC Tablet: Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.

Diclofenac SR Tablet:

  • Adult: 1 tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dose can be increased to 150 mg by supplementation with conventional tablets.
  • Children: 1-3 mg of diclofenac/kg body wt. daily in divided doses.
  • Elderly patients: In elderly or debilitated patients, the lowest effective dosage is recommended, although the pharmacokinetics of diclofenac sodium is not impaired to any clinically relevant extent in elderly patients.

Diclofenac Dispersible Tablet:

  • Adults: The recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg. In milder cases, 2 tablets of Diclofenac DT per day are sufficient. Diclofenac DT should preferably be taken before meals.
  • Children: Diclofenac is not recommended in children for other indications except juvenile rheumatoid arthritis where the recommended dose is 1-3 mg/kg body weight. Diclofenac DT is to be dropped into a half-glass of water and the liquid is to be stirred to aid dispersion before swallowing. There is no information on the use of Diclofenac DT for more than 03 months.

Diclofenac TR Capsule: One capsule daily. Diclofenac TR should be taken preferably after mealtimes.

Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg.

Diclofenac injection: For adults the usual dose is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily.

Diclofenac Gel: For external use only. Depending on the size of area to be treated, 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily. To the affected area gel should be rubbed in lightly. This gel may also be given in addition to further treatment with other dosage forms of Diclofenac.

Interaction

Diclofenac Sodium may have the following drug interactions:

Lithium and digoxin: Diclofenac may increase plasma concentrations of lithium and digoxin.

Anticoagulants: There are isolated reports of an increased risk of haemorrhage with the combined use of diclofenac and anticoagulant therapy, although clinical investigations do not appear to indicate any influence on anticoagulant effect.

Antidiabetic agents: Clinical studies have shown that diclofenac can be given together with oral antidiabetic agents without influencing their clinical effect.

Cyclosporin: Cases of nephrotoxicity have been reported in patients receiving cyclosporin and diclofenac concomitantly.

Methotrexate: Cases of serious toxicity have been reported when methotrexate and NSAIDs are given within 24 hours of each other.

Quinolone antimicrobials: Convulsions may occur due to an interaction between quinolones and NSAIDs.
Therefore, caution should be exercised when considering concomitant therapy of NSAID and quinolones.

Other NSAIDs and steroids: Co-administration of diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects. With aspirin, the plasma levels of each is lowered, although no clinical significance is known.

Contraindications

Contraindicated to the patients hypersensitive to any ingredient of the products. Peptic ulcer, hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents, Diclofenac is also contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor. This Gel should not be used under occlusive airtight dressings.

Side Effects

Diclofenac Sodium is generally well tolerated. Adverse effects are mild, rare and transient. At the starting of the treatment, however, patients may be sometimes complaining of epigastric pain, eructation, nausea and diarrhea or dizziness or headache. These effects are usually mild in nature. Peripheral edema and skin reactions, such as rash and eczema have also been encountered. Diclofenac Sodium Gel may cause local irritation and reddening of the skin and skin rash.

Pregnancy & Lactation

During pregnancy, Diclofenac should be employed only for compelling reasons. The lowest effective dose should be used. These types of drugs are not recommended during the first trimester of pregnancy. In view of insufficient clinical data, Diclofenac Sodium Gel is not recommended during pregnancy. A very insignificant quantity of Diclofenac may be detected in breast milk but no undesirable effects on the infant to be expected.

Precautions & Warnings

In rare instances where peptic ulceration or gastrointestinal bleeding occurs in patients under treatment with Diclofenac. In patients with advanced age should be kept under close observation. Diclofenac Sodium Gel should not be allowed to come in contact with the eyes or mucus membranes, after application the hands should be washed properly and not to be taken by mouth.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.

Available Brand Names

🌿
A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 0.55
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A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 2.00
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A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 14.10
🌿
A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 9.00
🌿
A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 15.00
🌿
A-Fenac

ACME Laboratories Ltd.

Unit Price : ৳ 13.00
🌿
A-Fenac SR

ACME Laboratories Ltd.

Unit Price : ৳ 3.50
🌿
Aid

Premier Pharmaceuticals Ltd.

Unit Price : ৳ 0.80
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Aid SR

Premier Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Aid TR

Premier Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Alcofen

Aexim Pharmaceuticals Ltd.

Unit Price : ৳ 0.70
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Alcofen SR

Aexim Pharmaceuticals Ltd.

Unit Price : ৳ 1.50
🌿
Alterin

Euro Pharma Ltd.

Unit Price : ৳ 1.00
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Alterin TR

Euro Pharma Ltd.

Unit Price : ৳ 3.00
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Anodyne

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 1.00
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Anodyne

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Anodyne SR

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
🌿
Apain-TR

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Apnac

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 0.80
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Apnac

Supreme Pharmaceutical Ltd.

Unit Price : ৳ Price not available.
🌿
Apnac SR

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 3.00
🌿
C-Fenac

Chemist Laboratories Ltd.

Unit Price : ৳ 11.13
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C-Fenac TR

Chemist Laboratories Ltd.

Unit Price : ৳ 3.00
🌿
Clofen TR

Cosmic Pharma Ltd.

Unit Price : ৳ 3.08
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Clofenac

Square Pharmaceuticals PLC

Unit Price : ৳ 2.00
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Clofenac

Square Pharmaceuticals PLC

Unit Price : ৳ 12.00
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Clofenac

Square Pharmaceuticals PLC

Unit Price : ৳ 16.00
🌿
Clofenac

Square Pharmaceuticals PLC

Unit Price : ৳ 20.00
🌿
Clofenac

Square Pharmaceuticals PLC

Unit Price : ৳ 40.00
🌿
Clofenac DT

Square Pharmaceuticals PLC

Unit Price : ৳ 4.02
🌿
Clofenac SR

Square Pharmaceuticals PLC

Unit Price : ৳ 5.00
🌿
Clonac TR

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Cosfenac SR

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 3.00
🌿
D-Fenac

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 12.68
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D-Fenac

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 25.00
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DCF

Decent Pharma Laboratories Ltd.

Unit Price : ৳ 0.60
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Deonac TR

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Dfc TR

Amulet Pharmaceuticals Ltd.

Unit Price : ৳ 2.50
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Diclo

Apollo Pharmaceutical Ltd.

Unit Price : ৳ 0.40
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Diclo TR

Apollo Pharmaceutical Ltd.

Unit Price : ৳ 3.00
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Diclofast SR

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 0.52
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 1.00
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 22.14
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 15.10
🌿
Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 9.06
🌿
Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 12.09
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 15.50
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Diclofen

Opsonin Pharma Ltd.

Unit Price : ৳ 20.00
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Diclofen SR

Opsonin Pharma Ltd.

Unit Price : ৳ 3.40
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Diclofenac

Pristine Pharmaceuticals Ltd

Unit Price : ৳ 0.88
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Diclofenac SR

Pristine Pharmaceuticals Ltd

Unit Price : ৳ 3.00
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DicloGel

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 97.00
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Diclomol

Mundipharma (BD) Pvt. Ltd.

Unit Price : ৳ 40.00
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Diclomol SR

Mundipharma (BD) Pvt. Ltd.

Unit Price : ৳ 4.00
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Diclon SR

Central Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Diclonac

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 8.50
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Diclonac TR

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 1.60
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Diclonil

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 0.80
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Diclonil SR

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Diclorex

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 0.54
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Diclorex

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 0.70
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Diclorex

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 9.50
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Diclorex RTD

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Diclovir

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 0.75
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Diclovir SR

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Difenac

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 0.90
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Dilock

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 0.50
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Dilock SR

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Dilock TR

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 3.0
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Diloren

OSL Pharma Limited

Unit Price : ৳ 1.50
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Diloren

OSL Pharma Limited

Unit Price : ৳ 40.00
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Diloren SR

OSL Pharma Limited

Unit Price : ৳ 4.00
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Dinac TR

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Dix-TR

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 2.80
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E-Fenac

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 0.50
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Edifenac

Edruc Limited

Unit Price : ৳ 0.83
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Edifenac-TR

Edruc Limited

Unit Price : ৳ 3.00
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Edifenac

Edruc Limited

Unit Price : ৳ 15.00
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Emov

Edruc Limited

Unit Price : ৳ 25.00
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Erdon

Aristopharma Ltd.

Unit Price : ৳ 100.00
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Erdon

Aristopharma Ltd.

Unit Price : ৳ 15.00
🌿
Erdon TR

Aristopharma Ltd.

Unit Price : ৳ 4.00
🌿
Fastfit

General Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
🌿
Fengel

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 19.68
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Fengel

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 1.00
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Fengel SR

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 3.00
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G-Diclofenac

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 1.01
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Geofenac TR

Biogen Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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G-Diclofenac

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 17.00
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Genac

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 1.20
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Genac

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 14.00
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Geofenac SR

Biogen Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Hi-Fenac

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 0.50
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Hi-Fenac TR

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Hipain TR

Pharmik Laboratories Ltd.

Unit Price : ৳ 2.60
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Hitflam

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 0.84
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Hitflam

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 7.62
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Hitflam

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 12.95
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Hitflam-SR

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 3.05
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Intafenac

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 0.75
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Jefenac

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 16.00
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Jefenac

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 1.50
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Jefenac TR

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Lardon TR

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Locopain-TR

Asiatic Laboratories Ltd.

Unit Price : ৳ 3.00
🌿
Medifen

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 13.00
🌿
Megafen

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 0.81
🌿
Megafen

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 10.18
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Megafen-SR

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 3.02
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Miclofen

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 0.84
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Miclofen TR

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 3.03
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Mobifen

ACI Limited

Unit Price : ৳ 0.88
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Mobifen

ACI Limited

Unit Price : ৳ 9.00
🌿
Mobifen

ACI Limited

Unit Price : ৳ 12.00
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Mobifen

ACI Limited

Unit Price : ৳ 15.00
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Mobifen SR

ACI Limited

Unit Price : ৳ 3.02
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Moov

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 60.00
🌿
Moov SR

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 2.50
🌿
Movonac TR

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Nasfen TR

National Drug Co. Ltd.

Unit Price : ৳ 2.50
🌿
Nasida SR

Delta Pharma Ltd.

Unit Price : ৳ 2.50
🌿
Neofen SR

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Neofenac SR

Modern Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
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Nopain

Drug International Ltd.

Unit Price : ৳ 15.00
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Norfen

Kumudini Pharma Ltd.

Unit Price : ৳ 1.00
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Norfen-SR

Kumudini Pharma Ltd.

Unit Price : ৳ 4.00
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Novarin

Amico Laboratories Ltd.

Unit Price : ৳ 12.90
🌿
Novarin SR

Amico Laboratories Ltd.

Unit Price : ৳ 2.50
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Orafen SR

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Orfenac-TR

Orion Pharma Ltd.

Unit Price : ৳ 3.01
🌿
Orgafen TR

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Pain Zero TR

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Painac-TR

Royal Pharmaceutical Ltd.

Unit Price : ৳ 3.00
🌿
Panfre

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
🌿
Panfre

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
🌿
Panfre SR

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Parafenac TR

Pristine Pharmaceuticals Ltd

Unit Price : ৳ 3.00
🌿
Penac

APC Pharma Ltd.

Unit Price : ৳ 0.85
🌿
Penac TR

APC Pharma Ltd.

Unit Price : ৳ 3.00
🌿
Proflam

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 0.51
🌿
Proflam SR

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 3.01
🌿
Pronac SR

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 2.52
🌿
Refain

Monicopharma Ltd.

Unit Price : ৳ 0.83
🌿
Refain

Monicopharma Ltd.

Unit Price : ৳ 9.50
🌿
Refain TR

Monicopharma Ltd.

Unit Price : ৳ 3.00
🌿
Relnac

Albion Laboratories Limited

Unit Price : ৳ 13.00
🌿
Renac TR

Reman Drug Laboratories Ltd.

Unit Price : ৳ 3.00
🌿
Reutren SR

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Rispain

Ethical Drugs Limited

Unit Price : ৳ 0.55
🌿
Rispain SR

Ethical Drugs Limited

Unit Price : ৳ 1.70
🌿
S-Fenac TR

Seema Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
S-Fenac TR

Seema Pharmaceuticals Ltd.

Unit Price : ৳ 1.20
🌿
Safenac TR

Marker Pharma Ltd.

Unit Price : ৳ 2.50
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Sifen TR

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 2.51
🌿
Tenac TR

Team Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Tolfenac SR

Globex Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Ultrafen SR

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 3.0
🌿
Velofen TR

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Verifen SR

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Verifen SR

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 3.01
🌿
Volcan

Biopharma Limited

Unit Price : ৳ 0.80
🌿
Volcan SR

Biopharma Limited

Unit Price : ৳ 3.01
🌿
Volicool

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
🌿
Volifen

Opsonin Pharma Ltd.

Unit Price : ৳ 250.00
🌿
Volifen

Opsonin Pharma Ltd.

Unit Price : ৳ 550.00
🌿
Volifen

Opsonin Pharma Ltd.

Unit Price : ৳ 100.00
🌿
Voligel

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 97.00
🌿
Voligel Max

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 170.00
🌿
Volpro 50

Mystic Pharmaceuticals Ltd.

Unit Price : ৳ 0.80
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Voltafen

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 55.18
🌿
Voltafen

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 97.29
🌿
Voltagel

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 20.00
🌿
Voltagel

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
🌿
Voltagel

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
🌿
Voltagel DS

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 70.00
🌿
Voltalin

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 31.00
🌿
Voltalin

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 60.00
🌿
Voltalin

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 35.00
🌿
Voltalin D

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 8.02
🌿
Voltalin Forte

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 8.50
🌿
Voltalin SR

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 11.03
🌿
Voltalin SR

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 18.00
🌿
Voltaren

Novartis (Bangladesh) Ltd.

Unit Price : ৳ 150.00
🌿
Voltarol

Techno Drugs Ltd.

Unit Price : ৳ 9.33
🌿
Voltid

Pharmasia Limited

Unit Price : ৳ 0.60
🌿
Voltid

Pharmasia Limited

Unit Price : ৳ 12.95
🌿
Voltid SR

Pharmasia Limited

Unit Price : ৳ 3.02
🌿
Volton TR

The White Horse Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Vurdon SR

Square Pharmaceuticals PLC

Unit Price : ৳ 3.01