Cyclizine Hydrochloride is indicated in-
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Cyclizine Hydrochloride is an US FDA approved antihistaminic antiemetic drug. It possesses anticholinergic and antiemetic properties. It reduces excitability of inner ear labyrinth and acts directly on vomiting (Emetic) centre in the brain stem.
Motion Sickness:
Postoperative Nausea & Vomiting, Meniere's disease:
Cyclizine Hydrochloride may have additive effects with alcohol and other CNS depressants e.g. hypnotics, tranquillisers, anaesthetics, antipsychotics & barbiturates. It enhances the soporific effect of pethidine & also counteract the haemodynamic benefits of opioid analgesics.
Hypersensitivity to the active substance or to the other excipients. Cyclizine is contraindicated in the presence of acute alcohol intoxication. The anti-emetic properties of cyclizine may increase the toxicity of alcohol.
Itching or skin rashes, swelling of the face, lips or throat, difficulty in breathing or wheeziness.
It is safe in pregnancy according to TGA category "A" & US FDA category "B". Cyclizine Hydrochloride is excreted in milk. So in case of lactating mother, precaution should be taken before taking Cyclizine Hydrochloride.
Cyclizine Hydrochloride should be used with caution and appropriate monitoring in patients with glaucoma, urinary retention, obstructive disease of the gastrointestinal tract, hepatic disease, hypertension, epilepsy, severe heart failure.
Anti-emetic drugs
Store below 30°C temperature.Protected from light & moisture.Keep all the medicines out of the reach of children.