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Cefuroxime Axetil + Clavulanic Acid

Indications

This combination is indicated for the treatment of infections caused by sensitive bacteria.

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes.
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase producing strains)
  • Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, E. coli.
  • Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains).
  • Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes.
  • Uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae.
  • Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
  • Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae.
  • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi.
  • Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae (including ampicillin-resistant strains) & Klebsiella spp.
  • Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis & Staphylococcus aureus (penicillinase and non-penicillinase producing strains)
  • Switch therapy (Injectable to oral)

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.

Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.

Dosage & Administration

Adolescents and adults (13 years and older)-

  • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
  • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
  • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
  • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days 
  • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
  • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
  • Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose
  • Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
  • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
  • Early Lyme disease: 500 mg b.i.d. for 20 days

Paediatric Patients (3 months to 12 years)-

  • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
  • Acute otitis media: 30 mg/kg/day b.i.d for 10 days
  • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
  • Impetigo: 30 mg/kg/day b.i.d for 10 days

Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Contraindications

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Side Effects

Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Pregnancy & Lactation

While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.

Therapeutic Class

Second generation Cephalosporins, Vaccines, Anti-sera & Immunoglobulin

Storage Conditions

Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.

Common Questions

What is this combination?

Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. This combination is indicated for the treatment of infections caused by sensitive bacteria.

What is this combination used for?

This combination is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.

How long does it take for this combination to take effect?

This combination starts working within 2-3 hours after taking it.

How long do the effects of this medicine last?

The effect of this combination lasts for an average duration of 4-8 hours.

This combination it safe to consume alcohol while taking this medicine?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is this combination a habit forming medicine?

No habit-forming tendencies were reported for this combination.

Can this medicine be taken during pregnancy?

This combination is safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.

Can this combination be taken while breast-feeding?

This combination is safe to use during breastfeeding. It enters into breast milk at low levels.

Quick Tips

  • You have been prescribed this combination medicine to treat bacterial infections, even if they have developed resistance.
  • Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
  • Take it with food to avoid an upset stomach.
  • Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
  • Stop taking this combination and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
  • Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Available Brand Names

🌿
Athexim CV

C2C Pharma Ltd.

Unit Price : ৳ 60.00
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Axeclav

Alco Pharma Ltd.

Unit Price : ৳ 35.00
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Axeclav

Alco Pharma Ltd.

Unit Price : ৳ 65.00
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Axeclav

Alco Pharma Ltd.

Unit Price : ৳ 250.00
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Axicef Plus

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Axicef Plus

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 65.00
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Axicef Plus

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 280.00
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Axim CV

Aristopharma Ltd.

Unit Price : ৳ 65.00
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Axim CV

Aristopharma Ltd.

Unit Price : ৳ 35.00
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Axim CV

Aristopharma Ltd.

Unit Price : ৳ 285.00
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Benkill CV

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Benkill CV

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Brocef CV

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Brocef CV

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Ceclav

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 30.00
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Ceclav

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Ceclav

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Cefaclav

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 20.00
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Cefaclav

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Cefaclav

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Cefaclav

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 265.00
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Cefotil Plus

Square Pharmaceuticals PLC

Unit Price : ৳ 35.00
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Cefotil Plus

Square Pharmaceuticals PLC

Unit Price : ৳ 60.00
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Cefotil Plus

Square Pharmaceuticals PLC

Unit Price : ৳ 285.00
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Cefurav Plus

Team Pharmaceuticals Ltd.

Unit Price : ৳ 34.50
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Cefurav Plus

Team Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Cefurav Plus

Team Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Cefurim CV

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 260.00
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Cefurim CV

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 33.00
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Cefurim CV

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Cefurino Plus

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Cefurino Plus

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Cefuroxime Plus

Pharmik Laboratories Ltd.

Unit Price : ৳ 60.00
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Cefusil CV

Silco Pharmaceutical Ltd.

Unit Price : ৳ 35.00
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Cefusil CV

Silco Pharmaceutical Ltd.

Unit Price : ৳ 60.00
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Cefuson Plus

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 30.00
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Cefuson Plus

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 50.00
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Cefuxet Plus

Chemist Laboratories Ltd.

Unit Price : ৳ 60.00
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Cefuxet Plus

Chemist Laboratories Ltd.

Unit Price : ৳ 35.00
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Cefuxim-CV

Albion Laboratories Limited

Unit Price : ৳ 38.40
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Cefuxim-CV

Albion Laboratories Limited

Unit Price : ৳ 66.00
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Ceroclav

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 30.00
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Ceroclav

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Ceroclav

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Cerox CV

ACI Limited

Unit Price : ৳ 285.00
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Cerox CV

ACI Limited

Unit Price : ৳ 21.06
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Cerox CV

ACI Limited

Unit Price : ৳ 35.00
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Cerox CV

ACI Limited

Unit Price : ৳ 60.00
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Clacef

OSL Pharma Limited

Unit Price : ৳ 18.00
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Clacef

OSL Pharma Limited

Unit Price : ৳ 35.00
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Clacef

OSL Pharma Limited

Unit Price : ৳ 55.00
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Clacef

OSL Pharma Limited

Unit Price : ৳ 265.00
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Claviator-CV

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 30.00
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Claviator-CV

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Claviator-CV

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Clavimax-CV

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Clavucure

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Unit Price : ৳ 34.00
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Clavucure

Kumudini Pharma Ltd.

Unit Price : ৳ 34.00
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Clavucure

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Unit Price : ৳ 55.00
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Clavucure

Kumudini Pharma Ltd.

Unit Price : ৳ 265.00
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Clavurox

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Unit Price : ৳ 60.00
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Clavurox

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Clavurox

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 285.00
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Clavusef

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Unit Price : ৳ 20.00
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Clavusef

Opsonin Pharma Ltd.

Unit Price : ৳ 35.00
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Clavusef

Opsonin Pharma Ltd.

Unit Price : ৳ 60.00
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Clavusef

Opsonin Pharma Ltd.

Unit Price : ৳ 265.00
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Clavutil

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Unit Price : ৳ 285.00
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Clavutil

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Clavutil

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Clavuxet

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 30.07
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Clavuxim

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 33.00
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Clavuxim

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Co-Axet

Orion Pharma Ltd.

Unit Price : ৳ 35.00
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Co-Axet

Orion Pharma Ltd.

Unit Price : ৳ 55.00
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Co-Axet

Orion Pharma Ltd.

Unit Price : ৳ 250.00
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Cosmotil

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 30.00
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Cosmotil

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 50.00
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Doctil Plus

Maks Drug Limited

Unit Price : ৳ 34.00
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Doctil Plus

Maks Drug Limited

Unit Price : ৳ 59.00
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Doctil Plus

Maks Drug Limited

Unit Price : ৳ 270.00
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Eurix CV

Ethical Drugs Limited

Unit Price : ৳ 30.00
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Eurix CV

Ethical Drugs Limited

Unit Price : ৳ 50.00
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Eurix CV

Ethical Drugs Limited

Unit Price : ৳ 250.00
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Famiclav

ACME Laboratories Ltd.

Unit Price : ৳ 35.00
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Famiclav

ACME Laboratories Ltd.

Unit Price : ৳ 60.00
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Famiclav

ACME Laboratories Ltd.

Unit Price : ৳ 265.00
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Fixcef Plus

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Fixcef Plus

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 34.50
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Fuclav

Drug International Ltd.

Unit Price : ৳ 18.10
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Fuclav

Drug International Ltd.

Unit Price : ৳ 35.00
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Fuclav

Drug International Ltd.

Unit Price : ৳ 57.00
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Furoclav

Renata Limited

Unit Price : ৳ 35.00
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Furoclav

Renata Limited

Unit Price : ৳ 35.00
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Furoclav

Renata Limited

Unit Price : ৳ 60.00
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Furoclav

Renata Limited

Unit Price : ৳ 265.00
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Furoget CV

Get Well Limited

Unit Price : ৳ 48.00
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Furoget CV

Get Well Limited

Unit Price : ৳ 28.00
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Furoget CV

Get Well Limited

Unit Price : ৳ 250.00
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Furonaaf-CV

Naafco Pharma Ltd.

Unit Price : ৳ 55.00
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Furonaaf-CV

Naafco Pharma Ltd.

Unit Price : ৳ 85.00
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Furonaaf-CV

Naafco Pharma Ltd.

Unit Price : ৳ 285.00
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Furotil Plus

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 270.00
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Furotil Plus

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 21.00
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Furotil Plus

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Furotil Plus

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Fuxtil CV

Pharmasia Limited

Unit Price : ৳ 34.00
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Fuxtil CV

Pharmasia Limited

Unit Price : ৳ 55.00
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Fuxtil CV

Pharmasia Limited

Unit Price : ৳ 250.00
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Kefuclav

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Kefuclav

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
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Kefuclav

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 285.00
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Meroclav

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 30.00
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Meroclav

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Meroclav

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
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Mexclav

Biopharma Limited

Unit Price : ৳ 35.00
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Mexclav

Biopharma Limited

Unit Price : ৳ 60.00
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Mexclav

Biopharma Limited

Unit Price : ৳ 252.00
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Neoclav

SMC Enterprise Ltd (Mfg. by: Jenphar Bangladesh Ltd.)

Unit Price : ৳ 30.00
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Neoclav

SMC Enterprise Ltd (Mfg. by: Jenphar Bangladesh Ltd.)

Unit Price : ৳ 50.00
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Nucef CV

Nuvista Pharma Ltd.

Unit Price : ৳ 35.00
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Nucef CV

Nuvista Pharma Ltd.

Unit Price : ৳ 60.00
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Probac Plus

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Probac Plus

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 30.00
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Rapiclav

Techno Drugs Ltd.

Unit Price : ৳ 30.00
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Rapiclav

Techno Drugs Ltd.

Unit Price : ৳ 50.00
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Rapiclav

Techno Drugs Ltd.

Unit Price : ৳ 250.00
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Recofast CV

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 31.00
🌿
Recofast CV

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Relacef Plus

Cosmic Pharma Ltd.

Unit Price : ৳ 28.00
🌿
Relacef Plus

Cosmic Pharma Ltd.

Unit Price : ৳ 28.00
🌿
Relacef Plus

Cosmic Pharma Ltd.

Unit Price : ৳ 48.00
🌿
Roclav

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
🌿
Roclav

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
🌿
Roclav

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
🌿
Rofuclav

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Rofuclav

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 85.00
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Roxibac Plus

Jenphar Bangladesh Ltd.

Unit Price : ৳ 35.00
🌿
Roxibac Plus

Jenphar Bangladesh Ltd.

Unit Price : ৳ 65.00
🌿
Roxiclav

Euro Pharma Ltd.

Unit Price : ৳ 55.00
🌿
Roxiclav

Euro Pharma Ltd.

Unit Price : ৳ 35.00
🌿
Roxilab Plus

Labaid Pharma Ltd.

Unit Price : ৳ 60.00
🌿
Roxilab Plus

Labaid Pharma Ltd.

Unit Price : ৳ 40.00
🌿
Roxilab Plus

Labaid Pharma Ltd.

Unit Price : ৳ 285.00
🌿
Roximax Plus

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
🌿
Roximax Plus

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 30.00
🌿
Roxtal XP

Everest Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Roxtal XP

Everest Pharmaceuticals Ltd.

Unit Price : ৳ 75.00
🌿
Secoclav

General Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
🌿
Secoclav

General Pharmaceuticals Ltd.

Unit Price : ৳ 65.00
🌿
Sharpkil Plus

One Pharma Ltd.

Unit Price : ৳ 32.00
🌿
Sharpkil Plus

One Pharma Ltd.

Unit Price : ৳ 55.00
🌿
Sharpkil Plus

One Pharma Ltd.

Unit Price : ৳ 265.00
🌿
Staxiclav

Delta Pharma Ltd.

Unit Price : ৳ 30.00
🌿
Staxiclav

Delta Pharma Ltd.

Unit Price : ৳ 50.00
🌿
Turboclav

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
🌿
Turboclav

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
🌿
Xiclav

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
🌿
Xiclav

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
🌿
Xiclav

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
🌿
Ximeclav

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 250.00
🌿
Ximeclav

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 34.50
🌿
Ximeclav

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 57.50
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Xinarox CV

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 35.00
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Xinarox CV

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 55.00
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Zerotil Plus

Beacon Pharmaceuticals PLC

Unit Price : ৳ 45.00
🌿
Zerotil Plus

Beacon Pharmaceuticals PLC

Unit Price : ৳ 70.00
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Zerotil plus

Beacon Pharmaceuticals PLC

Unit Price : ৳ 285.00
🌿
Zinaclav

DBL Pharmaceuticals Ltd.

Unit Price : ৳ 35.00
🌿
Zinaclav

DBL Pharmaceuticals Ltd.

Unit Price : ৳ 65.00