Lactulose
Indications
Constipation (Chronic Constipation): In every case of chronic constipation, initial treatment should consist of a diet rich in fiber (vegetables, salads, fruits etc.) a generous amount of liquids and much physical exercise. Lactulose is only to be taken when these measures prove insufficient.
Intestinal flora disturbances:
- In damaged to intestinal flora (e.g. following long-term antibiotic treatment)
- Gall bladder diseases
- Intestinal diseases (Colitis, Diverticulosis, Megacolon)
Increased blood ammonia levels (hyper ammoniemia in hepatopathy, portal-systemic encephalopathy)
* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন
Pharmacology
Lactulose is a synthetic disaccharide. Lactulose is metabolized in the colon by the saccharolytic bacteria, producing low molecular weight organic acids (mainly lactic acid), which lowers the pH of the colon contents, promote the retention of water by an osmotic effect; thus increasing peristaltic activity. Lactulose is minimally absorbed; therefore, the pharmacokinetics of the absorbed material are not relevant to the principal therapeutic action.
Dosage & Administration
In constipation ( chronic constipation):
- Adults: Initially 3-6 tea-spoons daily, In long-term therapy 1½-6 tea-spoons daily
- Children up to 14 years: Initially 3 tea-spoons daily, In long-term therapy 1-2 tea-spoons daily
- Infants and toddlers: Initially 1-2 tea-spoons daily, In long-term therapy 1 tea-spoon daily
In damaged intestinal flora:
- Adults: 1-2 tea-spoons daily
- Children: 1 tea-spoon daily
For reduction of blood ammonia level:
- Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily.
- In portal systemic encephalopathy: hourly doses of 6-9 tea-spoons of Lactulose solution may be used to induce the rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.
Interaction
There is no significant drug interactions with lactulose. The glycosidic effect of cardiac glycosides can be intensified by potassium deficiency in abuse.
Contraindications
Hypersensitivity to either galactose and or lactose; galactose-free diet, gastro-cardial symptom complex, suspected intestinal obstruction.
Side Effects
Occasionally flatulence, cramp and abdominal discomfort can occur at the beginning of treatment; this is rapidly eliminated by reducing the dose. Overdose can result in diarrhoea. In abuse, loss of electrolytes (primarily potassium).
Pregnancy & Lactation
US FDA Pregnancy Category of Lactulose is B. Studies show that Lactulose has no adverse effects. Decisions regarding use during pregnancy and lactation must be made by registered physician.
Precautions & Warnings
Lactulose should be administered with care to patients who are intolerant to lactulose. The dose used in the treatment of (pre) coma hepaticum is usually much higher and may need to be taken into consideration for diabetics.
Therapeutic Class
Osmotic purgatives
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Chemical Structures
Molecular Formula : C12H22O11
Chemical Structure : 
Overdose Effects
There have been no reports of accidental overdosage. In the event of acute overdosage it is expected that diarrhoea and abdominal cramps would be the major symptoms.
Available Brand Names
Sinalac
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 70.00
Sinalac
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 140.00
Sinalac
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 230.00
Rewat
Kumudini Pharma Ltd.
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Polylac
Silco Pharmaceutical Ltd.
Unit Price : ৳ 120.00
Osmolax
Square Pharmaceuticals PLC
Unit Price : ৳ 160.00
Osmolax
Square Pharmaceuticals PLC
Unit Price : ৳ 280.00
Onlac
One Pharma Ltd.
Unit Price : ৳ 140.00
Onlac
One Pharma Ltd.
Unit Price : ৳ 240.00
Mylac
Mystic Pharmaceuticals Ltd.
Unit Price : ৳ 75.00
Mylac
Mystic Pharmaceuticals Ltd.
Unit Price : ৳ 140.00
Loctoz
Amico Laboratories Ltd.
Unit Price : ৳ 100.00
Livax
Pacific Pharmaceuticals Ltd.
Unit Price : ৳ 140.00
Livax
Pacific Pharmaceuticals Ltd.
Unit Price : ৳ 250.00
Leaxe
Alco Pharma Ltd.
Unit Price : ৳ 140.42
Leaxe
Alco Pharma Ltd.
Unit Price : ৳ 250.75
Laxol
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 136.00
Lactulose H
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Unit Price : ৳ 110.00
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Monicopharma Ltd.
Unit Price : ৳ 100.00
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Unit Price : ৳ 100.00
Isolac
Concord Pharmaceuticals Ltd.
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E-Lax
Edruc Limited
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Dlac
Drug International Ltd.
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Dlac
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Dlac
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Contilos
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Conlax
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Avolose
Team Pharmaceuticals Ltd.
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Avolose
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Asilac
Asiatic Laboratories Ltd.
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Asilac
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Laclose
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Lactoben
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Lactu
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Laxolac
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Leolac
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Leolac
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Livoton
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Livoton
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Livoton
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Mebolos
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Mebolos
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Niprolac
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Niprolac
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Zenilac
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Xylose
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Veelac
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Tonilax
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