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Naproxen Sodium

Indications

Naproxen is indicated for the relief of sign and symptoms of-

rheumatoid arthritis
osteoarthritis
ankylosing spondylitis
juvenile arthritis
tendonitis
bursitis
acute gout

It is also indicated for the management of primary dysmenorrhea & pain.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

As with other non-selective NSAIDs, naproxen exerts it's clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. Although both enzymes contribute to prostaglandin production, they have unique functional differences. The COX-1 enzymes is constitutively active and can be found in normal tissues such as the stomach lining, while the COX-2 enzyme is inducible and produces prostaglandins that mediate pain, fever and inflammation. The COX-2 enzyme mediates the desired antipyretic, analgesic and anti-inflammatory properties offered by Naproxen, while undesired adverse effects such as gastrointestinal upset and renal toxicities are linked to the COX-1 enzyme.

Dosage & Administration

Naproxen oral preparations should be taken with water preferably after meals.

Naproxen Enteric Coated Tablet: Adult:

For rheumatoid arthritis/ osteoarthritis/ ankylosing spondylitis: For adults 500-1000 mg per day taken in two devided doses at 12- hour intervals. The maintenance dose is usually 500 mg per day taken in two devided doses at 12 - hour intervals. The total daily dose of Naproxen should not exceed 1000 mg maintaining 12-hour intervals.
For acute gout: 750 mg should be given initially, then 250 mg every 8 hours until the attack has passed. Children under 16 years are not recommended.
For dysmenorrhoea: For adults 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for upto 5 days, if necessary.
For other indications like analgesia and acute musculoskeletal disorders: 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals, if necessary.

Naproxen Enteric Coated Tablet: Children: Children under 16 years are not recommended.

Naproxen Suspension: Children:

For juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hour intervals. Therapy in children under 2 years of age is not recommended. The following may be used as a guide for dosage of suspension:

13 kg (29 lb) 2.5 mL b.i.d.
25 kg (55 lb) 5 mL b.i.d.
38 kg (84 lb) 7.5 mL b.i.d.

Naproxen Gel: Is to be applied 2-6 times a day as required and is not recommended for use in children.

Interaction

ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.
Antacids & Sucralfate: delay the absorption of Naproxen.
Aspirin: increase adverse effects.
Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.
Methotrexate: enhance the toxicity of Methotrexate.
Warfarin: increase the risk of GI bleeding.
Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.

Contraindications

Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Side Effects

Most frequently reported side effects include following:

Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
Central Nervous System: Headache, vertigo, drowsiness.
Dermatological: Pruritus (itching), purpura.
Cardiovascular: Edema, palpitation.
Others: Visual disturbances, hearing disturbances.

Pregnancy & Lactation

Most non-steroidal anti-inflammatory drugs may have an adverse effect on the fetus through their pharmacological properties. Naproxen causes a delay in parturition in animals and has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen. The use of Naproxen in the first and third trimesters requires careful balancing of the benefits to the mother against the possible risks to the fetus. Naproxen is excreted in small amounts in the breast milk for nursing mothers. The amount of Naproxen distributed into breast milk is considered by some authorities to be too small to be harmful to a breast-fed infant although some manufacturers recommend that breast feeding should be avoided during Naproxen therapy.

Precautions & Warnings

Renal effects: As with other non-steroidal anti- inflammatory drugs, long-term administration of naproxen to animal has resulted in renal papillary necrosis and other abnormal renal pathology. In humans, there have been reports of acute interstitial nephritis, hematuria, proteinuria and occasionally nephrotic syndrome associated with Naproxen-containing products and others NSAIDs since they have been marketed. Naproxen and its metabolites are eliminated primarily by the kidneys; therefore, the drug should be used with caution in patients with significantly impaired renal function, and the monitoring of serum creatinine and/or creatinine clearance is advised in these patients. Caution should be used if the drug is given to the patients with creatinine clearance of less than 20ml/min because accumulation of naproxen metabolites has been seen in such patients.

Hepatic effects: There have been a few reports of moderate to severe jaundice attributed to Naproxen.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.

Available Brand Names

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Annova

Beacon Pharmaceuticals PLC

Unit Price : ৳ 16.00

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Annova

Beacon Pharmaceuticals PLC

Unit Price : ৳ 9.00

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Anaflex SR

ACI Limited

Unit Price : ৳ 14.09

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Anaflex

ACI Limited

Unit Price : ৳ 80.00

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Anaflex

ACI Limited

Unit Price : ৳ 16.00

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Anaflex

ACI Limited

Unit Price : ৳ 9.00

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Aktivex

OSL Pharma Limited

Unit Price : ৳ 6.00

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Aktivex

OSL Pharma Limited

Unit Price : ৳ 11.00

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Bpxen

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 7.00

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Bpxen

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 4.00

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Dolwin

SMC Enterprise Ltd (Mfg. by: Jenphar Bangladesh Ltd.)

Unit Price : ৳ 7.00

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Diproxen CR

Drug International Ltd.

Unit Price : ৳ 11.00

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Diproxen

Drug International Ltd.

Unit Price : ৳ 60.20

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Diproxen

Drug International Ltd.

Unit Price : ৳ 8.00

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Diproxen

Drug International Ltd.

Unit Price : ৳ 5.00

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Eprox

Euro Pharma Ltd.

Unit Price : ৳ 8.00

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Ecless

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Ecless

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 70.00

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Ecless

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 9.00

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Ecless

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 6.00

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Gloxen

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 7.00

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Gloxen

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 4.00

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Fritt

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 7.03

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Fritt

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 4.01

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Indoprox

Indo Bangla Pharmaceutical

Unit Price : ৳ 5.33

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H-Nap

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

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NAN

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 7.73

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Naid

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 7.52

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Naid

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 4.00

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Indoprox

Indo Bangla Pharmaceutical

Unit Price : ৳ 7.00

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Napier

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 9.00

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Napgin

Biopharma Limited

Unit Price : ৳ 7.00

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Napdas

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 14.00

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Napasin

Skylab Pharmaceuticals Ltd.

Unit Price : ৳ 4.20

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Naproben

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 9.00

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Napro-A

ACME Laboratories Ltd.

Unit Price : ৳ 10.00

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Napro-A

ACME Laboratories Ltd.

Unit Price : ৳ 6.00

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Napro

Aristopharma Ltd.

Unit Price : ৳ 11.00

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Napro

Aristopharma Ltd.

Unit Price : ৳ 7.00

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Napren

Alco Pharma Ltd.

Unit Price : ৳ 9.03

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Napoxol

Centeon Pharma Ltd.

Unit Price : ৳ 15.00

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Napoxen

Edruc Limited

Unit Price : ৳ 7.00

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Napoxen

Edruc Limited

Unit Price : ৳ 4.00

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Napix

Modern Pharmaceuticals Ltd.

Unit Price : ৳ 7.00

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Naprocid

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 7.02

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Naprofast

Albion Laboratories Limited

Unit Price : ৳ 8.50

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Napronaaf

Naafco Pharma Ltd.

Unit Price : ৳ 10.35

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Napronil

Pharmasia Limited

Unit Price : ৳ 8.00

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Naproson

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 4.07

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Naproson

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 7.06

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Naprosyn

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 9.00

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Naprosyn

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 16.00

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Naprosyn

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 130.00

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Naprox

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 7.00

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Naprox

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

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Naprox

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 90.00

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Naprox

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 70.00

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Naproxen

Amico Laboratories Ltd.

Unit Price : ৳ 10.22

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Naproxen

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

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Naproxen

Guardian Healthcare Ltd.

Unit Price : ৳ 7.00

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Naproxen SR

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Naproxin

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 4.26

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Naproxin

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

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