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Albendazole

Indications

Albendazole is indicated in single and mixed infestations of-

  • Hookworm (Ancylostoma, Necator)
  • Roundworm (Ascaris)
  • Threadworm (Enterobius)
  • Whipworm (Trichuris)
  • Strongyloides
  • Tapeworm
  • Opisthorchi
  • Hydatid.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Albendazole is a broad spectrum anthelmintic. Albendazole exhibits vermicidal, ovicidal and larvicidal activities. The drug is thought to exert its anthelmintic effect by blocking glucose uptake in the susceptible helminths, thereby depleting the energy level until it becomes inadequate for survival. Immobilization is followed by the parasite. These events may be a consequence of the binding and subsequent inhibition of parasite tubulin polymerization by Albendazole and its metabolites, although the drug also binds to human tubulin. Albendazole is extensively metabolized, probably in the liver. Albendazole is poorly absorbed from the gastrointestinal tract but rapidly undergoes extensive first-pass metabolism. The principal metabolite albendazole sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs. It is excreted in the urine together with other metabolites.

Dosage & Administration

Adults & children over 2 years:

  • 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus.
  • In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated. 

Children of 1-2 years: Recommended dose is a single dose of 200 mg (5 ml suspension).

Children under 1 year: Not recommended.

In Hydatid disease (Echinococcosis):

  • Albendazole is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg.
  • A dose of 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) is used for patients weighing less than 60 kg.
  • For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles.
  • For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years.
  • In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days is used.

Interaction

No interaction involving Albendazole, either pharmacodynamic or pharmacokinetic, has been reported.

Contraindications

Neonates: Albendazole is not normally used in neonates.

Children: Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children.

Pregnant woman: Albendazole should not be given during pregnancy or women thought to be pregnant. No information is available on placental transfer.

Concurrent disease: There is no evidence to suggest that dose should be altered in renal, hepatic or cardiac failure.

Side Effects

Gastrointestinal disturbances, headache, dizziness, changes in liver enzymes, rarely reversible alopecia; rash, fever, blood disorders including leucopenia and pancytopenia reported; allergic shock if cyst leakage; convulsion and meningism in cerebral disease.

Pregnancy & Lactation

US FDA Pregnancy category of Albendazole is C. So, Albendazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Precautions & Warnings

Blood counts and liver function tests before treatment and twice during each cycle; breastfeeding; exclude pregnancy before starting treatment. Albendazole should only be used in the treatment of Echinococcosis if there is constant medical supervision with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts

Therapeutic Class

Anthelmintic

Storage Conditions

-Keep in a dry place, away from light and heat. Keep out of the reach of children.

Available Brand Names

🌿
AB-DS

Prime Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Aben-DS

Team Pharmaceuticals Ltd.

Unit Price : ৳ 4.50
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ABZ

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
🌿
Adze

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 4.01
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AH

Drug International Ltd.

Unit Price : ৳ 5.05
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AH

Drug International Ltd.

Unit Price : ৳ 20.10
🌿
AL-DS

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
Alba

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 4.50
🌿
Albamax DS

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
Albazol DS

Central Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
🌿
Alben

Square Pharmaceuticals PLC

Unit Price : ৳ 23.00
🌿
Alben-DS

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
Albenda DS

Aexim Pharmaceuticals Ltd.

Unit Price : ৳ 3.40
🌿
Albendol

Globex Pharmaceuticals Ltd.

Unit Price : ৳ 3.50
🌿
Albendol

Globex Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
🌿
Albendox

Indo Bangla Pharmaceutical

Unit Price : ৳ 4.00
🌿
Albengen DS

Biogen Pharmaceuticals Ltd.

Unit Price : ৳ 3.50
🌿
Albentas

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
Albezen

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 3.00
🌿
Albezole

Apollo Pharmaceutical Ltd.

Unit Price : ৳ 3.80
🌿
Albicon DS

The White Horse Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Albol-DS

Ethical Drugs Limited

Unit Price : ৳ 3.50
🌿
Albrex

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 3.50
🌿
Alda

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 15.00
🌿
Alda DS

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 4.00
🌿
Aldaben

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 20.00
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Aldaben-DS

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
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Aldes DS

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Aldew

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 4.00
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Aldin DS

Techno Drugs Ltd.

Unit Price : ৳ 4.00
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Aldoben DS

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
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Ale DS

Aztec Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Almex

Square Pharmaceuticals PLC

Unit Price : ৳ 5.02
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Almex

Square Pharmaceuticals PLC

Unit Price : ৳ 23.00
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Almin

Kumudini Pharma Ltd.

Unit Price : ৳ 15.00
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Almin

Kumudini Pharma Ltd.

Unit Price : ৳ 4.00
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Alphin DS

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
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Alpro

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 4.00
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Alzed

General Pharmaceuticals Ltd.

Unit Price : ৳ 3.32
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Alzolux DS

Pharmik Laboratories Ltd.

Unit Price : ৳ 4.50
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Anthel DS

Seema Pharmaceuticals Ltd.

Unit Price : ৳ 4.20
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Autoben

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
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Azole

Biopharma Limited

Unit Price : ৳ 5.00
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Azole

Biopharma Limited

Unit Price : ৳ 20.00
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Parnil DS

Euro Pharma Ltd.

Unit Price : ৳ 5.00
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Orben

Avarox Pharmaceuticals Ltd.

Unit Price : ৳ 3.76
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Nematox DS

Chemist Laboratories Ltd.

Unit Price : ৳ 5.00
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Mebel

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 23.00
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Luban DS

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 3.30
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Laben DS

Premier Pharmaceuticals Ltd.

Unit Price : ৳ 3.52
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Krimizole

Mystic Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
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Helben DS

Modern Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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H Ben

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 3.60
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G-Albendazole

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 3.45
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Exworm

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Exworm

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
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Estazol

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 20.00
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Estazol

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Elmin-DT

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 4.26
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Elmin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 4.50
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Eben-DS

Edruc Limited

Unit Price : ৳ 4.00
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Eben

Edruc Limited

Unit Price : ৳ 15.00
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Durazol

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 15.00
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Durazol

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Cosben

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 4.50
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Colaz

Cosmic Pharma Ltd.

Unit Price : ৳ 19.00
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Colaz

Cosmic Pharma Ltd.

Unit Price : ৳ 5.00
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Chuben DS

Alco Pharma Ltd.

Unit Price : ৳ 5.00
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Chir DS

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 5.14
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Benz

Belsen Pharmaceuticals Ltd.

Unit Price : ৳ 3.20
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Benfast

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 4.02
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Benda DS

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 3.50
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Ben-A

ACME Laboratories Ltd.

Unit Price : ৳ 5.01
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Ben-A

ACME Laboratories Ltd.

Unit Price : ৳ 23.00
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Zoben

Amico Laboratories Ltd.

Unit Price : ৳ 4.50
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Zoben

Amico Laboratories Ltd.

Unit Price : ৳ 18.00
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Wormex

Syntho Laboratories Ltd.

Unit Price : ৳ 14.00
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Wormex

Syntho Laboratories Ltd.

Unit Price : ৳ 3.50
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Vermin-DS

Nipa Pharmaceuticals Ltd.

Unit Price : ৳ 4.50
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Vermikil

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 3.53
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Vermikil

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 15.11
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Vermid

Square Pharmaceuticals PLC

Unit Price : ৳ 5.00
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Verben

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 15.00
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Verben

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 4.00
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Unizole-DS

Union Pharmaceuticals Ltd

Unit Price : ৳ 4.00
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Triben DS

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 3.35
🌿
Triben

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 13.97
🌿
Sintel

ACI Limited

Unit Price : ৳ 5.02
🌿
Sintel

ACI Limited

Unit Price : ৳ 23.00
🌿
Silben

ACI Limited

Unit Price : ৳ 5.00
🌿
R-Zol

Reman Drug Laboratories Ltd.

Unit Price : ৳ 4.00
🌿
Qben DS

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
Q Ben DS

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 5.00
🌿
R-Zol

Square Pharmaceuticals PLC

Unit Price : ৳ 4.00