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Cefpodoxime Proxetil

Indications

Cefpodoxime is indicated for the treatment of infections caused by susceptible microorganism, listed below:

  • Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis (including beta-lactamase producing strains).
  • Pharyngitis/tonsillitis caused by Streptococcus pyogenes.
  • Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae and Moraxella catarrhalis.
  • Community acquired pneumonia caused by S. pneumoniae or H. influenza (including beta-lactamase-producing strains).
  • Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains only), or M. catarrhalis.
  • Skin and skin structure infections caused by Staphylococcus aureus, Streptococcus pyogenes.
  • Uncomplicated urinary tract infections caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis or Staphylococcus saprophyticus.
  • Uncomplicated gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains).
  • Rectal gonococcal infections in women due to Neisseria gonorrhoeae (including penicillinase-producing strains).

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Cefpodoxime is an oral 3rd generation cephalosporin, which has good stability to beta lactamases and activity against Gram negative and Gram positive bacteria. It is indicated for the treatment of infections either before the infecting organism has been identified. It is a prodrug its active metabolite is Cefpodoxime. Approximately 29 to 33% of Cefpodoxime excreted unchanged in the urine in 12 hours.

Cefpodoxime is indicated for the treatment of patients infected with susceptible strains of microorganisms which include a wide range of gram-positive & gram-negative bacteria. As it is highly stable in presence of β-lactamase enzyme, so it is more effective against gram-positive bacteria than other 3rd generation oral cephalosporins. The susceptible organisms include gram-positive bacteria eg. S. aureus (including penicillinase producing strains), S. saprophyticus, S. pneumoniae, S. pyogenes, S. agalactiae, P. magnus and gram-negative bacteria eg. E. coli, K. pneumoniae, H. influenzae (including β-lactamase producer & Ampicillin resistant strains), M. catarrhalis, N. gonorrhoeae (including penicillinase producing strains), P. mirabilis, C. diversus, H. parainfluenzae, K. oxytoca, P. vulgaris, P. rettgeri.

Dosage & Administration

Adults and Adolescents (13 years and older)-

  • Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days
  • Acute maxillary sinusitis: 200 mg 12 hourly, 10 day
  • Community-acquired pneumonia: 200 mg 12 hourly, 14 days
  • Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days
  • Skin and skin structure: 400 mg 12 hourly, 7 to 14 days
  • Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days
  • Uncomplicated gonorrhea: single dose of 200 mg
  • Rectal gonococcal infections in women: single dose of 200 mg

Infants and Pediatric Patients (2 months to 12 years)-

  • Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days
  • Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days
  • Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days

Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance <30ml/min) the dosing intervals should be increased to 24 hourly.

Patients with liver cirrhosis: Cefpodoxime Proxetil pharmacokinetics in cirrhotic patients are similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Interaction

Antacids: Concomitant administration of high doses of antacids (sodium bicarbonate and aluminium hydroxide) or H 2 blockers reduce peak plasma level by 24% to 42% and the extent of absorption by 27% to 32%, respectively.

Probenecid: Renal excretion of cefpodoxime was inhibited by probenecid and resulted in an approximately 31% increase in AUC.

Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime Proxetil is administered concomitantly with compounds of known nephrotoxic potential.

Contraindications

Cefpodoxime Proxetil is contraindicated in patients with a known allergy to Cefpodoxime or to the cephalosporin group of antibiotics.

Side Effects

Cefpodoxime has very few side effects. The side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children incidence of fungal skin rash is more than adults.

Pregnancy & Lactation

Cefpodoxime was neither teratogenic nor embryocidal in animal trial. There is, however, no adequate and well-controlled study of Cefpodoxime Proxetil use in pregnant woman. The drug should be used during pregnancy only if clearly needed. Because Cefpodoxime is excreted in human milk, a decision should be made wheather to discontinue breast-feeding or to discontinue the drug.

Precautions & Warnings

In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of Cefpodoxime Proxetil should be reduced. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other broad spectrum antibiotics, prolonged use of Cefpodoxime Proxetil may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient’s condition is essential.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Reconstitution

For 50 ml suspension: Add 30 ml (6 teaspoonful or with the help of the provided cup) of cooled boil water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

Note: Shake the suspension well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.

Available Brand Names

🌿
Cefdox

ACI Limited

Unit Price : ৳ 98.67
🌿
Cefdox

ACI Limited

Unit Price : ৳ 60.41
🌿
Cefdox

ACI Limited

Unit Price : ৳ 22.13
🌿
Cefdox

ACI Limited

Unit Price : ৳ 37.00
🌿
Cefdox DS

ACI Limited

Unit Price : ৳ 176.19
🌿
Cefipod

Asiatic Laboratories Ltd.

Unit Price : ৳ 98.00
🌿
Cefipod

Asiatic Laboratories Ltd.

Unit Price : ৳ 60.00
🌿
Cefipod

Asiatic Laboratories Ltd.

Unit Price : ৳ 25.00
🌿
Cefipod

Asiatic Laboratories Ltd.

Unit Price : ৳ 14.00
🌿
Cefipod DS

Asiatic Laboratories Ltd.

Unit Price : ৳ 175.00
🌿
Cefobid

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 42.00
🌿
Cefobid

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
🌿
Cefodim

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 22.00
🌿
Cefodim

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
🌿
Cefodim

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Cefodox

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 22.00
🌿
Cefodox

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Cefokid

Euro Pharma Ltd.

Unit Price : ৳ 98.00
🌿
Cefokid DS

Euro Pharma Ltd.

Unit Price : ৳ 175.00
🌿
Cefomin

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 96.36
🌿
Cefoprox

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
🌿
Cefoprox DS

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 175.00
🌿
Ceforan

Drug International Ltd.

Unit Price : ৳ 28.10
🌿
Ceforan

Drug International Ltd.

Unit Price : ৳ 75.25
🌿
Ceforan

Drug International Ltd.

Unit Price : ৳ 140.00
🌿
Ceforan

Drug International Ltd.

Unit Price : ৳ 28.10
🌿
Ceforan

Drug International Ltd.

Unit Price : ৳ 17.05
🌿
Ceforan DS

Drug International Ltd.

Unit Price : ৳ 175.00
🌿
Cefpod

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 22.00
🌿
Cepdoxim

Alco Pharma Ltd.

Unit Price : ৳ 20.00
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Cepdoxim

Alco Pharma Ltd.

Unit Price : ৳ 30.06
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Cepdoxim

Alco Pharma Ltd.

Unit Price : ৳ 90.27
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Cepoxid

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
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Cepoxid

Credence Pharmaceuticals Ltd. (Mfg. by: Apex Pharmaceuticals Ltd.)

Unit Price : ৳ 41.00
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CP

ACME Laboratories Ltd.

Unit Price : ৳ 98.65
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CP

ACME Laboratories Ltd.

Unit Price : ৳ 60.40
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Desbac

General Pharmaceuticals Ltd.

Unit Price : ৳ 98.68
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Dofixim

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 21.00
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Dofixim

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
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Dxproxil

Monicopharma Ltd.

Unit Price : ৳ 98.00
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E-Pod

Edruc Limited

Unit Price : ৳ 40.00
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E-Pod

Edruc Limited

Unit Price : ৳ 96.00
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Emiprox

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 90.00
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Emiprox DS

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 170.00
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Epoxim

Peoples Pharma Ltd.

Unit Price : ৳ 35.00
🌿
Epoxim

Peoples Pharma Ltd.

Unit Price : ৳ 180.00
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Epoxim

Peoples Pharma Ltd.

Unit Price : ৳ 98.00
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Epoxim

Peoples Pharma Ltd.

Unit Price : ৳ 20.00
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Kidcef

Beacon Pharmaceuticals PLC

Unit Price : ৳ 100.00
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Neoprox

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 98.37
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Neoprox

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 60.23
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Pedicef

Orion Pharma Ltd.

Unit Price : ৳ 98.66
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Pedicef

Orion Pharma Ltd.

Unit Price : ৳ 60.39
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Pedicef DS

Orion Pharma Ltd.

Unit Price : ৳ 176.19
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Podo

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 98.29
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Podoxi

Chemist Laboratories Ltd.

Unit Price : ৳ 98.00
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Rovantin

Opsonin Pharma Ltd.

Unit Price : ৳ 60.42
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Rovantin

Opsonin Pharma Ltd.

Unit Price : ৳ 95.66
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Rovantin

Opsonin Pharma Ltd.

Unit Price : ৳ 14.05
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Rovantin

Opsonin Pharma Ltd.

Unit Price : ৳ 25.16
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Rovantin DS

Opsonin Pharma Ltd.

Unit Price : ৳ 175.66
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Roxetil

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
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Sefox

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 22.08
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Sefox

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
🌿
Starin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 22.00
🌿
Starin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
🌿
Starin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
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Starin DS

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 150.00
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Starin PD

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Sudoxim

S.N. Pharmaceutical Ltd.

Unit Price : ৳ 95.00
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Supoxim

Ethical Drugs Limited

Unit Price : ৳ 98.00
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Taxetil

Aristopharma Ltd.

Unit Price : ৳ 99.00
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Taxetil

Aristopharma Ltd.

Unit Price : ৳ 195.00
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Taxetil

Aristopharma Ltd.

Unit Price : ৳ 62.00
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Taxetil DS

Aristopharma Ltd.

Unit Price : ৳ 175.00
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Toraxim

Delta Pharma Ltd.

Unit Price : ৳ 60.00
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Toraxim

Delta Pharma Ltd.

Unit Price : ৳ 98.00
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Trucef

Renata Limited

Unit Price : ৳ 98.37
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Trucef

Renata Limited

Unit Price : ৳ 60.23
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Trucef DS

Renata Limited

Unit Price : ৳ 175.66
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Vanprox

Square Pharmaceuticals PLC

Unit Price : ৳ 98.65
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Vanprox

Square Pharmaceuticals PLC

Unit Price : ৳ 60.40
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Vercef

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
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Vercef

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Vercef DS

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 175.00
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Victorin

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 98.29
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Victorin

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 60.18
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Victorin

Novo Healthcare and Pharma Ltd.

Unit Price : ৳ 40.00
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Xepodox

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 98.29
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Xepodox

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 60.18
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Ximeprox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 17.00
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Ximeprox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 25.00
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Ximeprox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 98.00
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50 ml bottle

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 195.00
🌿
Ximeprox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
🌿
Ximeprox DS

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 175.00
🌿
Ximocef

Kumudini Pharma Ltd.

Unit Price : ৳ 150.00
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Ximocef

Kumudini Pharma Ltd.

Unit Price : ৳ 40.00
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Ximocef-40

Kumudini Pharma Ltd.

Unit Price : ৳ 95.00
🌿
Xpotil

Cosmic Pharma Ltd.

Unit Price : ৳ 98.00
🌿
Zedoxim

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Zedoxim

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 20.00
🌿
Zedoxim

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
🌿
Zedoxim

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 60.00