Ketotifen Fumarate (Oral)
Indications
Ketotifen is indicated in the following conditions-
- For the prophylactic treatment of bronchial asthma.
- Symptomatic treatment of allergic conditions including rhinitis and conjunctivitis.
- For alleviating the complications of itching, pain and tenderness associated with neurofibroma.
- Symptomatic treatment of allergy such as hayfever, urticaria.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন
Pharmacology
Ketotifen has anti-allergic properties and has been used similarly, to sodium chromoglycate in the prophylactic treatment of asthma. It also has the properties of an antihistamine. Ketotifen possesses marked anti-anaphylactic properties and is effective in preventing an asthmatic attacks. Ketotifen exerts as sustained inhibitory effect on histamine reactions, which can be clearly dissociated from its anti-anaphylactic properties. Experimental investigations in asthmatic subjects have shown that Ketotifen is as effective orally as a selective mast cell stabilizer administered by inhalation. Antihistamines were ineffective in those tests. The effectiveness of Ketotifen has been studied in long-term clinical trials. Asthma attacks were reduced in number, severity and duration and in some cases, the patients were completely freed from attacks. Progressive reduction of corticosteroids and/or bronchodilators was also possible. The prophylactic activity of Ketotifen may take several weeks to become fully established. Ketotifen will not abort established attacks of asthma.
Dosage & Administration
Adults: 1 mg twice daily with food. If necessary the dose may be increased to 2 mg twice daily in severe cases.
Children above 3 years: 1 mg twice daily with food. Patients known to be easily sedated should begin treatment with 0.5 to 1 mg at night for the first few days or as directed by the physician.
Use in elderly: Same as adult dose or as advised by the physician.
Interaction
Ketotifen may potentiate the effects of sedatives, hypnotics, antihistamines and alcohols. A reversible fall in the platelet count has been observed in a few patients receiving Tifen concomitantly with oral antidiabetic agents and it has been suggested that this combination should therefore be avoided.
Contraindications
A reversible fall in the platelet count has been observed in a few patients receiving Ketotifen concomitantly with oral antidiabetic agent and it has been suggested that this combination should therefore be avoided. Although there is no evidence of any teratogenic effect, recommendations for Ketotifen in pregnancy or when breast feeding can not be given.
Side Effects
Drowsiness and in isolated cases, dry mouth and slight dizziness may occur at the beginning of treatment but usually disappear spontaneously after a few days.
Pregnancy & Lactation
Although there is no evidence of any teratogenic effect, Ketotifen in pregnancy and lactation is not recommended.
Precautions & Warnings
It is important to continue the previous treatment for a minimum of two weeks after starting Ketotifen to avoid the possibility of exacerbation of asthma. This applies specially to systemic corticosteroids and ACTH because of the possible existence of adrenocortical insufficiency in steroid dependent patient. If inter current infection occurs, Ketotifen treatment must be supplemented by specific antimicrobial therapy. During the first day of treatment with Ketotifen, reactions may be impaired and patients should be warned not to take charge of vehicle or machinery until the effect of Ketotifen treatment on the individual is known. Patients should be advised to avoid alcoholic drinks. Ketotifen may potentiate the effects of sedatives, hypnotics, antihistamines and alcohol.
Therapeutic Class
Cromoglycate & related drugs
Storage Conditions
Store in a cool and dry place, protect from light. Keep out of the reach of children.
Chemical Structures
Molecular Formula : C19H19NOS
Chemical Structure :
Overdose Effects
The reported features of overdosage include confusion, drowsiness, headache, bradycardia, respiratory depression etc. should be watched for. Elimination of the drug with gastric lavage or emessis is recommended. Otherwise, general supportive treatment is all that is required shall be instituted.
Available Brand Names
Ketokid
Euro Pharma Ltd.
Unit Price : ৳ 50.00
Ketof
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 2.50
Ketodil
Techno Drugs Ltd.
Unit Price : ৳ 45.00
Ketifen
ACME Laboratories Ltd.
Unit Price : ৳ 3.52
Kefton
Zenith Pharmaceuticals Ltd.
Unit Price : ৳ 44.00
Kefat
Medicon Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
Imunofen
Kumudini Pharma Ltd.
Unit Price : ৳ 50.00
Fenat
Drug International Ltd.
Unit Price : ৳ 65.00
Fenat
Drug International Ltd.
Unit Price : ৳ 80.00
Ethifen
Ethical Drugs Limited
Unit Price : ৳ 2.50
Broket
Orion Pharma Ltd.
Unit Price : ৳ 3.00
Asmiket
One Pharma Ltd.
Unit Price : ৳ 70.00
Asmafen
Globe Pharmaceuticals Ltd.
Unit Price : ৳ 55.00
Asfen
Virgo Pharmaceuticals Ltd.
Unit Price : ৳ 40.00
Allerkit
Monicopharma Ltd.
Unit Price : ৳ 40.00
Alarid
Square Pharmaceuticals PLC
Unit Price : ৳ 3.00
Airnaaf
Naafco Pharma Ltd.
Unit Price : ৳ 75.00
Aerofen
Silva Pharmaceuticals Ltd.
Unit Price : ৳ 55.00
Aerofen
Silva Pharmaceuticals Ltd.
Unit Price : ৳ 1.51
Alafix
Jenphar Bangladesh Ltd.
Unit Price : ৳ 75.00
Alarid
Square Pharmaceuticals PLC
Unit Price : ৳ 75.00
Aptofen
Apollo Pharmaceutical Ltd.
Unit Price : ৳ 40.00
Asmafen
Globe Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Asmiket
One Pharma Ltd.
Unit Price : ৳ 2.30
Asprofen
Rephco Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Broket
Orion Pharma Ltd.
Unit Price : ৳ 60.00
Ethifen
Ethical Drugs Limited
Unit Price : ৳ 50.00
Fenat
Drug International Ltd.
Unit Price : ৳ 3.00
Kafu
Concord Pharmaceuticals Ltd.
Unit Price : ৳ 60.00
Kefat
Medicon Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Kefton
Zenith Pharmaceuticals Ltd.
Unit Price : ৳ 1.15
Ketocure
Benham Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
Ketof
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 66.00
Ketofimed
MedRx Life Science Ltd.
Unit Price : ৳ 55.00
Ketokid
Euro Pharma Ltd.
Unit Price : ৳ 2.50
Ketomar
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
Ketopac
Pacific Pharmaceuticals Ltd.
Unit Price : ৳ 50.00
Ketorif
Biopharma Limited
Unit Price : ৳ 3.00
Ziten
Pharmadesh Laboratories Ltd.
Unit Price : ৳ 40.00
Ziten
Pharmadesh Laboratories Ltd.
Unit Price : ৳ 2.00
Zadit
Popular Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Zadifen
UniMed UniHealth Pharmaceuticals Ltd.
Unit Price : ৳ 50.00
Zadifen
UniMed UniHealth Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Totifen
Renata Limited
Unit Price : ৳ 63.00
Totifen
Renata Limited
Unit Price : ৳ 3.50
Toti
Eskayef Pharmaceuticals Ltd.
Unit Price : ৳ 62.00
Toti
Eskayef Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
Tosma
Alco Pharma Ltd.
Unit Price : ৳ 65.00
Tosma
Alco Pharma Ltd.
Unit Price : ৳ 2.00
Tomart
Desh Pharmaceuticals Ltd.
Unit Price : ৳ 50.00
Tomart
Desh Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Toma
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 30.00
Toma
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Toma
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 2.50
Tokn
Alkad Laboratories
Unit Price : ৳ 50.00
Tofenver
Veritas Pharmaceuticals Ltd.
Unit Price : ৳ 2.50
Tofen
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 75.00
Tofen
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Tink
Ad-din Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Tifsi
Silco Pharmaceutical Ltd.
Unit Price : ৳ 50.00
Tifsi
Silco Pharmaceutical Ltd.
Unit Price : ৳ 2.00
Tifen
Somatec Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Tifen
Somatec Pharmaceuticals Ltd.
Unit Price : ৳ 48.00
Ticofen
Chemist Laboratories Ltd.
Unit Price : ৳ 60.00
Stafen
Aristopharma Ltd.
Unit Price : ৳ 75.00
Stafen
Aristopharma Ltd.
Unit Price : ৳ 4.00
Sesofen
Rangs Pharmaceuticals Ltd.
Unit Price : ৳ 55.00
S-Kit
Sharif Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
S-Kit
Sharif Pharmaceuticals Ltd.
Unit Price : ৳ 55.00
Ridair
Team Pharmaceuticals Ltd.
Unit Price : ৳ 2.50
Ridair
Team Pharmaceuticals Ltd.
Unit Price : ৳ 55.00
Prosma
ACI Limited
Unit Price : ৳ 4.00
Prosma
ACI Limited
Unit Price : ৳ 76.00
Orotifen
General Pharmaceuticals Ltd.
Unit Price : ৳ 75.00
Orotifen
General Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Minia
Novo Healthcare and Pharma Ltd.
Unit Price : ৳ 45.13
Masfen
OSL Pharma Limited
Unit Price : ৳ 60.00
Masfen
OSL Pharma Limited
Unit Price : ৳ 2.50
Ktin
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Ktin
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 50.14
Kofen
Opsonin Pharma Ltd.
Unit Price : ৳ 55.00
Kofen
Opsonin Pharma Ltd.
Unit Price : ৳ 2.50
Kiti
Beacon Pharmaceuticals PLC
Unit Price : ৳ 3.00
Kiti
Beacon Pharmaceuticals PLC
Unit Price : ৳ 75.00
Kitaf
Avarox Pharmaceuticals Ltd.
Unit Price : ৳ 40.00
Kidocold
DBL Pharmaceuticals Ltd.
Unit Price : ৳ 70.00
Ketoxen
Astra Biopharmaceuticals Ltd.
Unit Price : ৳ 3.00
Ketotifen
Pristine Pharmaceuticals Ltd
Unit Price : ৳ 2.50
Ketotifen
Amico Laboratories Ltd.
Unit Price : ৳ 2.50
Ketotif
Delta Pharma Ltd.
Unit Price : ৳ 2.00
Ketosma
Leon Pharmaceuticals Ltd.
Unit Price : ৳ 45.00
Ketosma
Leon Pharmaceuticals Ltd.
Unit Price : ৳ 2.00
Ketorif
Biopharma Limited
Unit Price : ৳ 60.00
Ketopac
Pacific Pharmaceuticals Ltd.
Unit Price : ৳ 2.30
Ketomax
Albion Laboratories Limited
Unit Price : ৳ 72.00
Ketomax
Albion Laboratories Limited
Unit Price : ৳ 3.00
Ketomar
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Ketokid
Euro Pharma Ltd.
Unit Price : ৳ 2.50
Ketokid
Euro Pharma Ltd.
Unit Price : ৳ 50.00
Ketof
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 2.50
Ketof
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 66.00
Ketodil
Techno Drugs Ltd.
Unit Price : ৳ 45.00
Ketocure
Benham Pharmaceuticals Ltd.
Unit Price : ৳ 65.00
Ketifen
ACME Laboratories Ltd.
Unit Price : ৳ 75.00