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Cefuroxime Axetil

Indications

It is indicated for the treatment of infections caused by sensitive bacteria.

Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes.
Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase producing strains)
Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, E. coli
Acute bacterial exacerbation of chronic bronchitis and Secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains).
Skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes.
Urinary tract infections caused by E.coli or Klebsiella pneumoniae.
Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae.
Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Cefuroxime is a well-characterized and effective antibacterial agent, which has broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains. Cefuroxime has good stability to bacterial β-lactamase and consequently, is active against many ampicillin-resistant and amoxycillin-resistant strains.

Interaction

No potentially hazardous interactions have been reported.

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.

Side Effects

Adverse effects to Cefuroxime have occurred infrequently and have been generally mild and transient in nature. Effects reported include rashes and gastrointestinal disturbances. As with other antibiotics, prolonged use may result in the overgrowth of non susceptible organisms e.g. Candida.

Pregnancy & Lactation

US FDA pregnancy category of Cefuroxime is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Cefuroxime have been shown to be excreted in human milk. So, caution should be exercised when Cefuroxime is administered to a nursing woman.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis. Cephalosporin antibiotics may in general be given safely to patients who are hypersensitive to penicillin although cross reactions have reported. Cefuroxime has shown, that is not likely to be a problem at the recommended to dose levels.

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30o C), away from light & moisture. Keep out of the reach of children.

Reconstitution

For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion.

For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period.

For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period.

Dosage

Tablet or Suspension-

Adolescents and adults (13 years and older)-

Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
Uncomplicated Gonorrhoea: 1000 mg Single dose
Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
Early Lyme disease: 500 mg b.i.d. for 20 days

Paediatric Patients (3 months to 12 years)-

Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
Acute otitis media: 30 mg/kg/day b.i.d for 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
Impetigo: 30 mg/kg/day b.i.d for 10 days

Parenteral-

Adult: 750 mg three times daily by IM or IV injection. In severe infections, dose can be increased upto 1.5 gm three times daily by IV injection. The frequency may be increased to four times daily, if necessary, giving total daily doses of 3 to 6 gms.
Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60 mg/kg/day is appropriate for most infections.
Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses.
Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia; up to 3 further doses of 750 mg may be given by IV/IM injection every 8 hours for high risk procedures.
Pneumonia: 1.5 gm IV injection twice daily for 2-3 days, followed by 500 mg twice daily (oral) for 7-10 days.
Acute exacerbations of chronic bronchitis: 750 mg twice daily (IM or IV injection) for 2-3 days, followed by 500 mg twice daily (oral) for 5-10 days. (Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.)
In Gonorrhoea: Adult: 1.5 gm as a single dose (as 2 x 750mg injections intramuscularly with different sites, e.g. each buttock).

In Meningitis:

Adult: 3 gm IV injection three times daily.
Children (above 3 months of age): 200-240 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement.
Neonate: 100 mg/kg/day by IV injection at initial dose, reduced to 50 mg/kg/day, When clinically indicated.

In bone and joint infections:

Adult: 1.5 gm IV injection four times daily.
Children (above 3 months of age): 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.

Administration

The use of freshly reconstituted solution is recommended. However, it maintains potency for at least 24 hours at room temperature or 48 hours at 5o C

Available Brand Names

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Adetil

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 25.00

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Adetil

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 45.00

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Adetil

Supreme Pharmaceutical Ltd.

Unit Price : ৳ 45.00

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Athexim

C2C Pharma Ltd.

Unit Price : ৳ 45.00

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Axefur

Amulet Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Axefur

Amulet Pharmaceuticals Ltd.

Unit Price : ৳ 45.13

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Axefur

Amulet Pharmaceuticals Ltd.

Unit Price : ৳ 198.00

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Axet

Orion Pharma Ltd.

Unit Price : ৳ 15.10

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Axet

Orion Pharma Ltd.

Unit Price : ৳ 25.16

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Axet

Orion Pharma Ltd.

Unit Price : ৳ 45.30

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Axet

Orion Pharma Ltd.

Unit Price : ৳ 216.45

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Axet

Orion Pharma Ltd.

Unit Price : ৳ 125.85

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Axetil

Alco Pharma Ltd.

Unit Price : ৳ 12.08

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Axetil

Alco Pharma Ltd.

Unit Price : ৳ 25.08

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Axetil

Alco Pharma Ltd.

Unit Price : ৳ 45.17

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Axetil

Alco Pharma Ltd.

Unit Price : ৳ 190.58

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Axibid

Nuvista Pharma Ltd.

Unit Price : ৳ 25.08

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Axibid

Nuvista Pharma Ltd.

Unit Price : ৳ 45.13

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Axicef

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 30.00

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Axicef

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 50.00

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Axicef

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 250.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 15.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 25.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 45.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 225.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 125.00

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Axim

Aristopharma Ltd.

Unit Price : ৳ 200

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Bactikil

Edruc Limited

Unit Price : ৳ 25.00

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Bactikil

Edruc Limited

Unit Price : ৳ 45.00

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Bactikil

Edruc Limited

Unit Price : ৳ 198.00

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Benkill

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Benkill

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 45.00

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Brocef

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 24.00

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Brocef

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 43.00

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C-2

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 25.00

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C-2

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 45.13

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C-2

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 198.00

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Cefobac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 25.09

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Cefobac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 45.17

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Cefobac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 198.75

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Cefobac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 125.27

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Cefotil

Square Pharmaceuticals PLC

Unit Price : ৳ 25.17

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Cefotil

Square Pharmaceuticals PLC

Unit Price : ৳ 45.29

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Cefotil

Square Pharmaceuticals PLC

Unit Price : ৳ 240.00

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Cefotil

Square Pharmaceuticals PLC

Unit Price : ৳ 132.00

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Cefotil

Square Pharmaceuticals PLC

Unit Price : ৳ 250.00

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Cefoxil

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 200.00

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Cefroxil

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cefroxil

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cefroxil

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 195.74

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Cefstar

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 15.05

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Cefstar

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 25.08

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Cefstar

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 45.16

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Cefstar

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 190.00

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Cefu M

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 125.00

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Cefuact

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cefuact

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 45.00

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Cefuact

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 199.00

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Cefunix

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cefunix

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 40.00

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Cefunix

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ 190.00

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Cefurim

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 25.10

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Cefurim

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 45.17

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Cefurim

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 200.00

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Cefurino

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cefusil

Silco Pharmaceutical Ltd.

Unit Price : ৳ 25.00

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Cefusil

Silco Pharmaceutical Ltd.

Unit Price : ৳ 45.00

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Cefuson

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 25.00

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Cefuson

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 45.00

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Cefuxet

Chemist Laboratories Ltd.

Unit Price : ৳ 25.00

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Cefuxet

Chemist Laboratories Ltd.

Unit Price : ৳ 45.00

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Cefuxet

Chemist Laboratories Ltd.

Unit Price : ৳ 225.00

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Cerox-A

ACI Limited

Unit Price : ৳ 30.00

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Cerox-A

ACI Limited

Unit Price : ৳ 50.00

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Cerox-A

ACI Limited

Unit Price : ৳ 300.00

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Cerox-A

ACI Limited

Unit Price : ৳ 175.00

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Cerox-A

ACI Limited

Unit Price : ৳ 275.00

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Ceroxime

Asiatic Laboratories Ltd.

Unit Price : ৳ 25.00

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Ceroxime

Asiatic Laboratories Ltd.

Unit Price : ৳ 45.00

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Ceroxime

Asiatic Laboratories Ltd.

Unit Price : ৳ 198.00

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Ceroxime

Asiatic Laboratories Ltd.

Unit Price : ৳ 125.00

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Cexitil

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Cexitil

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 45.00

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Dexatil

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 25.00

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Dexatil

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 198.00

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Doctil

Maks Drug Limited

Unit Price : ৳ 198.0030.00

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Doctil

Maks Drug Limited

Unit Price : ৳ 50.00

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Doctil

Maks Drug Limited

Unit Price : ৳ 235.00

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Doctil

Maks Drug Limited

Unit Price : ৳ 170.00

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Eliroxime

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 25.00

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Eliroxime

Reliance Pharmaceuticals Ltd.

Unit Price : ৳ 170.34

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Eurix

Ethical Drugs Limited

Unit Price : ৳ 25.00

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Eurix

Ethical Drugs Limited

Unit Price : ৳ 45.00

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Eurix

Ethical Drugs Limited

Unit Price : ৳ 190.00

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Famicef

ACME Laboratories Ltd.

Unit Price : ৳ 27.50

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Famicef

ACME Laboratories Ltd.

Unit Price : ৳ 50.00

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Famicef

ACME Laboratories Ltd.

Unit Price : ৳ 325.00

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Fightex

Guardian Healthcare Ltd.

Unit Price : ৳ 25.00

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Fightex

Guardian Healthcare Ltd.

Unit Price : ৳ 45.00

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Fixcef

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 30.00

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Fixcef

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 50.00

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Fixcef

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 199.00

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Furex

Drug International Ltd.

Unit Price : ৳ 25.10

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Furex

Drug International Ltd.

Unit Price : ৳ 45.15

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Furex

Drug International Ltd.

Unit Price : ৳ 230.00

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Furex

Drug International Ltd.

Unit Price : ৳ 130.00

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Furex

Drug International Ltd.

Unit Price : ৳ 220.00

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Furocef

Renata Limited

Unit Price : ৳ 15.06

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Furocef

Renata Limited

Unit Price : ৳ 25.09

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Furocef

Renata Limited

Unit Price : ৳ 45.17

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Furocef

Renata Limited

Unit Price : ৳ 225.00

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Furocef

Renata Limited

Unit Price : ৳ 125.47

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Furocef

Renata Limited

Unit Price : ৳ 200.75

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Furocef

Renata Limited

Unit Price : ৳ 160.00

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Furocef

Renata Limited

Unit Price : ৳ 55.21

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Furocef DS

Renata Limited

Unit Price : ৳ 250.00

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Furoget

Get Well Limited

Unit Price : ৳ 24.00

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Furoget

Get Well Limited

Unit Price : ৳ 44.00

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Furoget

Get Well Limited

Unit Price : ৳ 195.00

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Furotec

APC Pharma Ltd.

Unit Price : ৳ 45.00

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