Pantoprazole Sodium
Indications
Pantoprazole is indicated where suppression of acid secretion has therapeutic benefit; i.e
- Peptic ulcer diseases
- Gastroesophageal reflux diseases
- Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
- Eradication of Helicobacter pylori (in combination with antibiotics)
- Zollinger-Ellison Syndrome
* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন
Pharmacology
Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.
Dosage & Administration
Oral:
- Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.
- Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
- Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.
- Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.
- Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment.
- Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.
IV Injection:
- Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
- Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
- Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
- Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour
- Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.
Interaction
No significant drug interactions have been observed in clinical studies.
Contraindications
Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.
Side Effects
Pantoprazole is well tolerated in both short-term and long-term treatment. Headache and diarrhea are the common side effects and rarely included side effects are abdominal pain, flatulence, rash, insomnia and hyperglycemia.
Pregnancy & Lactation
US FDA Pregnancy Category of Pantoprazole is B. There are, however, no adequate and well-controlled studies in pregnant woman. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk. So, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.
Precautions & Warnings
Patients should be cautioned that Pantoprazole tablet should not be split, chewed or crushed. Long-term therapy of Pantoprazole may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.
Chemical Structures
Molecular Formula : C16H15F2N3O4S
Chemical Structure: 
Common Questions
What is Pantoprazole?
Pantoprazole is a proton pump inhibitor. It suppresses the final step in gastric acid production. It is used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome.
How long do I need to use Pantoprazole before I see improvement in my condition?
Pantoprazole is to be taken till the time you see an improvement in your health conditions.
At what frequency do I need to use Pantoprazole?
Pantoprazole should be taken in the dosage as prescribed by the doctor.
Should I use Pantoprazole empty stomach, before food or after food?
Pantoprazole should be taken prior to the meal, approximately 30 minutes before it, in the prescribed dosage.
What are the instructions for the storage and disposal of Pantoprazole?
Pantoprazole should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
What are the effects of Pantoprazole older adults?
Pantoprazole may increase the risk for bone fractures, especially with longer use, higher doses in older adults. Consult your doctor about ways to prevent bone loss/fracture.
How long does it take for Pantoprazole to work?
You should start to feel better within 2 to 3 days. It may take up to 4 weeks for this medication to work properly so you may still have some symptoms during this time.
Is Pantoprazole safe?
Yes, Pantoprazole is relatively safe. It is advised to consult the doctor before consuming this drug.
Does Pantoprazole cause weight gain?
In rare cases, the consumption of this drug can cause weight gain. You are advised to consult your doctor for any weight-related concern.
What are the side effects of Pantoprazole?
The side effects of Pantoprazole aren't that common. Still, people face the following issues sometimes - headache, diarrhea, constipation, and allergic reaction.
Can I take Pantoprazole if I am pregnant or breastfeeding?
Though Pantoprazole isn’t a serious issue for pregnant or breastfeeding person, it’s advised not to take medicine unless prescribed by your doctor.
What should I do if I miss a dose of Pantoprazole?
If you miss a dose of Pantoprazole, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time.
Overdose Effects
There are no known symptoms of overdosage in humans. Since Pantoprazole is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.
Reconstitution
Direction for use of IV injection: Pantoprazole lyophilized powder and 0.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. Pantoprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml 0.9% Sodium Chloride Injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes. Use only freshly prepared solution. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours.
Direction for use of IV infusion: Pantoprazole IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes. Pantoprazole IV infusion should be reconstituted with 10 ml of 0.9% Sodium Chloride Injection and further diluted (admixed) with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer's Injection to a final volume of 100 ml. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours prior to further dilution. The admixed solution may be stored at room temperature (up to 30° C) and must be used within 24 hours from the time of initial reconstitution.
Available Brand Names
Pantonix
Incepta Pharmaceuticals Ltd.
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Gaspain
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Exipro
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Exipro
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Cospra
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AUP
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AUP
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Otonix
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Otonix
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Novapan
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Nixpan
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Nixpan
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Neopanta
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P-Lock
One Pharma Ltd.
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P-Lock
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Unit Price : ৳ 7.00
P-Gut
Globe Pharmaceuticals Ltd.
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P-Gut
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P-40
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P-20
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Panosa
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Panloc
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Pamel
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Pamel
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Unit Price : ৳ 6.00
Panoz
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Panprazo
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Unit Price : ৳ 4.50
Panoz
Astra Biopharmaceuticals Ltd.
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Panotem
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Panprin
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Unit Price : ৳ 3.00
Panprin
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Unit Price : ৳ 5.00
Panpro
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Unit Price : ৳ 5.50
Panpro
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Panpro
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Unit Price : ৳ 70.00
Pansec
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Pansec
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Unit Price : ৳ 6.00
Pansec
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Unit Price : ৳ 8.00
Pansos
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Pansos
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Pantac
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Pantac
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Unit Price : ৳ 6.00
Pantaloc
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Pantex
ACI Limited
Unit Price : ৳ 8.00
Pantex
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Pantid
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Pantid
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Unit Price : ৳ 100.00
Pantex
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Unit Price : ৳ 110.00
Pantium
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Panto
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Panto
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Unit Price : ৳ 6.00
Panto SP
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Unit Price : ৳ 3.00
Pantobex
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Unit Price : ৳ 5.00
Pantobex
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Pantobio
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Unit Price : ৳ 4.75
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Unit Price : ৳ 5.00
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Rangs Pharmaceuticals Ltd.
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Pantodac
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Unit Price : ৳ 4.00
Pantodac
Ziska Pharmaceuticals Ltd.
Unit Price : ৳ 6.00
Pantodac
Ziska Pharmaceuticals Ltd.
Unit Price : ৳ 100.00
Pantogut
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Unit Price : ৳ 70.26
Pantofast
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Unit Price : ৳ 3.00
Pantogen
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Unit Price : ৳ 5.01
Pantogen
General Pharmaceuticals Ltd.
Unit Price : ৳ 7.03
Pantogut
Popular Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Pantogut
Popular Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Pantohil
Goodman Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Pantohil
Goodman Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Pantolam
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Unit Price : ৳ 3.00
Pantolok
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Pantolok
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Pantolok
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Unit Price : ৳ 80.00
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Unit Price : ৳ 6.00
Pantomak
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Unit Price : ৳ 8.00
Panton-AX
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Unit Price : ৳ 4.00
Panton-AX
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Unit Price : ৳ 9.00
Pantonix
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Unit Price : ৳ 7.00
Pantopan
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Unit Price : ৳ 5.00
Pantopra
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Unit Price : ৳ 4.50
Pantopra
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Unit Price : ৳ 6.50
Pantonix
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Unit Price : ৳ 100.00
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Unit Price : ৳ 80.00
Pantoprazole
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Unit Price : ৳ 5.00
Pantoprazole
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Unit Price : ৳ 7.00
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SMC Enterprise Ltd (Mfg. by: Jenphar Bangladesh Ltd.)
Unit Price : ৳ 4.50
Pantoraz
Premier Pharmaceuticals Ltd.
Unit Price : ৳ 3.00
Pantoraz
Premier Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
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Silva Pharmaceuticals Ltd.
Unit Price : ৳ 4.50
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Unit Price : ৳ 5.02
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Benham Pharmaceuticals Ltd.
Unit Price : ৳ 6.00
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Unit Price : ৳ 8.00
Pantover
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Unit Price : ৳ 85.00
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Credence Pharmaceuticals Ltd. (Mfg. by: Apex Pharmaceuticals Ltd.)
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Panzer
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Unit Price : ৳ 4.02
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Protium
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Unit Price : ৳ 7.00
Proton-P
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Unit Price : ৳ 7.00
Proton-P
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Unit Price : ৳ 5.00
Proton-P
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Unit Price : ৳ 80.00
Protonil
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Unit Price : ৳ 6.00
Protonil
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Unit Price : ৳ 9.00
Protopa
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Protozin
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Unit Price : ৳ 6.00
Protozin
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PZ-20
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Unit Price : ৳ 4.00
PZ-40
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Unit Price : ৳ 6.00
Topra
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Unit Price : ৳ 4.00
Topra
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Unit Price : ৳ 5.03
Trupan
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Unit Price : ৳ 10.00
Trupan
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Unit Price : ৳ 7.00
Trupan
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Unit Price : ৳ 90.00
U-Pepton
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Unit Price : ৳ 4.00
Zenopan
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Unit Price : ৳ 5.00
Zopan
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Zopan
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Unit Price : ৳ 6.02