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Ketorolac Tromethamine

Indications

Ketorolac Tromethamine is indicated for the short-term management of moderate to severe acute post-operative pain. Ketorolac ophthalmic solution helps relieve pain, inflammation, and light sensitivity after ocular surgery. It may also be used to decrease eye inflammation or redness caused by seasonal allergies.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Ketorolac Tromethamine is a potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs). It acts by inhibiting the cyclooxygenase enzyme system and hence inhibits the prostaglandin synthesis. It demonstrates a minimal anti-inflammatory effect at its analgesic dose.

Dosage & Administration

Tablet: Recommended dose is 10 mg every 4-6 hours. It should be used short-term only (up to 7 days) and are not recommended for chronic use. Doses exceeding 40 mg/day is not recommended.

Injection: Ketorolac injection may be used as a single or multiple doses, on a regular or when necessary schedule for the management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting. When administering Ketorolac injection, the IV bolus must be given over no less than 15 seconds. The IM administration should be given slowly and deeply into the muscle. The analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM. Duration of analgesic effect is usually 4 to 6 hours.

Single-Dose Treatment-
IM Dosing (Adult):

  • Patients <65 years of age: One dose of 60 mg.
  • Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 30 mg.

IV Dosing (Adult):

  • Patients <65 years of age: One dose of 30 mg.
  • Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 15 mg.

IV or IM Dosing (2 to 16 years of age):

  • IM Dosing: One dose of 1 mg/kg up to a maximum of 30 mg.
  • IV Dosing: One dose of 0.5 mg/kg up to a maximum of 15 mg.

Multiple-Dose Treatment (IV or IM)-

  • Patients <65 years of age: The recommended dose is 30 mg Ketorolac injection every 6 hours. The maximum daily dose should not exceed 120 mg. Patients >65 years of age, renally impaired patients and patients less than 50 kg: The recommended dose is 15 mg Ketorolac injection every 6 hours. The maximum daily dose for these populations should not exceed 60 mg. For breakthrough pain, do not increase the dose or the frequency of Ketorolac Tromethamine.
  • Conversion from Parenteral to Oral Therapy: Ketorolac tablets may be used either as monotherapy or as follow-on therapy to parenteral Ketorolac. When Ketorolac tablets are used as a follow-on therapy to parenteral Ketorolac, the total combined daily dose of ketorolac (oral + parenteral) should not exceed 120 mg in younger adult patients or 60 mg in elderly patients on the day the change of formulation is made. On subsequent days, oral dosing should not exceed the recommended daily maximum of 40 mg. Ketorolac IM should be replaced by Ketorolac tablet as soon as feasible. The total duration of combined parenteral and oral treatment should not exceed 5 days.

Eye Drops: Adults: 1 drop in each eye 4 times daily.

Interaction

Other NSAIDs or aspirin: Increase the side effects of ketorolac Tromethamine.
Anti-coagulants: Enhance anti-coagulant effect.
Beta Blocker: Reduce the anti-hypertensive effect .
ACE Inhibitors: Increase the risk of renal impairment.
Methotrexate: Enhance the toxicity of methotrexate.

Contraindications

Ketorolac is contraindicated in patients having hypersensitivity to this drug or other NSAIDs. It should not be used in children under 16 years of age. lt is also contraindicated as prophylactic analgesic before surgery.

Side Effects

Commonly occurring side effects are nausea, vomiting, gastro-intestinal bleeding, melana, peptic ulcer, pancreatitis, anxiety, drowsiness, headache, excessive thirst, fatigue, bradycardia, hypertension, palpitation, chest pain, infertility in female and pulmonary edema.

Pregnancy & Lactation

US FDA Pregnancy category of Ketorolac Tromethamine is C. So, Ketorolac Tromethamine should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Precautions & Warnings

Caution should be exercised in patients over the age of 65 years. Caution should also be taken in patients with active or suspected peptic ulcer or gastrointestinal bleeding or asthma and liver dysfunction.

Eye Drops: Patients with evidence of corneal epithelial breakdown should immediately discontinue use of topical NSAIDs and should be closely monitored for corneal health. Lopadol ophthalmic solution should not be administered while wearing contact lenses.

Therapeutic Class

Drugs used for Rheumatoid Arthritis, Non-Opioid Analgesics

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Available Brand Names

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Actifast

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Unit Price : ৳ 10.00
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Acupain

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Arolak

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Kelac

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K-Lac

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Inket

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Eurolac

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Eurolac

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Etolac

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Doltro

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Kelac

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Emodol

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Eket

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Doltro

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Doloket

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Xiroket

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Xidolac

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10 mg/ml

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Unit Price : ৳ 30.00
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Winop

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Winop

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Winop

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Toro

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Toro

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Unit Price : ৳ 10.00
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Torax

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Unit Price : ৳ 60.00
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Torax

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Unit Price : ৳ 100.00
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Torax

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Unit Price : ৳ 20.00
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Toramax

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Unit Price : ৳ 190.00
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Toramax

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Unit Price : ৳ 110.00
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Toramax

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Unit Price : ৳ 30.00
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Toradolin

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Toradolin

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Tolec

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Tolec

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Tolec

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Todol

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Todol

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Unit Price : ৳ 100.00
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Todo

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Todol

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Todol

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Temoket

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Temoket

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Surpim

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Surpim

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Surpim

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Surpim

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Surgidol

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Surgidol

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Unit Price : ৳ 45.00
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SB-Ketor

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Unit Price : ৳ 10.00
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Sanoket

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Unit Price : ৳ 95.29
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Sanoket

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Unit Price : ৳ 55.38
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Sanoket

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Unit Price : ৳ 10.03
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Rotek

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Unit Price : ৳ 50.15
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Rotek

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Rotalac

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Rotalac

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Rotalac

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Romilac

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Romilac

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Romilac

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Unit Price : ৳ 80.00
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Romilac

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Unit Price : ৳ 60.00
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Romilac

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Unit Price : ৳ 15.00
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Rolamax

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Rolafen

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Rolac NS

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Unit Price : ৳ 170.00
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Rolac MDT

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Unit Price : ৳ 13.00
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Rolac

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Unit Price : ৳ 95.36
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Rolac

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Unit Price : ৳ 55.21
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Rolac

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Unit Price : ৳ 32.13
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Rolac

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Unit Price : ৳ 12.00
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Roket

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Unit Price : ৳ 10.00
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Roket

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Unit Price : ৳ 95.00
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Roket

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Unit Price : ৳ 55.00
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Repopain

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Unit Price : ৳ 55.00
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Repopain

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 10.03
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Recular

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Unit Price : ৳ 80.30
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Petrolac

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Unit Price : ৳ 10.00
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Petorolac

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Unit Price : ৳ 10.00
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Orc

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Unit Price : ৳ 11.60
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Ostelac

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Unit Price : ৳ 10.00
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Painfree

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Unit Price : ৳ 10.00
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Painlok

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Unit Price : ৳ 10.00
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Pair

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Unit Price : ৳ 12.00
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Pair

Drug International Ltd.

Unit Price : ৳ 55.00
🌿
Pair

Drug International Ltd.

Unit Price : ৳ 70.25
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Perilac

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Unit Price : ৳ 12.00
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Perilac

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Unit Price : ৳ 60.00
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Perilac

Biopharma Limited

Unit Price : ৳ 95.00
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Oradol

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Unit Price : ৳ 95.00
🌿
Oradol

Aristopharma Ltd.

Unit Price : ৳ 55.00
🌿
Oradol

Aristopharma Ltd.

Unit Price : ৳ 12.00
🌿
Ofpain

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 80.24
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Ofpain

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 55.16
🌿
Ofpain

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 55.16
🌿
Ofpain

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 10.03
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Nouranz

Arges Life Science Limited

Unit Price : ৳ 10.00
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Minolac

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Unit Price : ৳ 105.00
🌿
Minolac

ACI Limited

Unit Price : ৳ 60.00
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Minolac

ACI Limited

Unit Price : ৳ 12.00
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Maxdol

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 90.00
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Maxdol

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Maxdol

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 12.00
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Lupelac

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Unit Price : ৳ 10.00
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Lopadol

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Unit Price : ৳ 80.30
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Lixidol

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Unit Price : ৳ 10.00
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Lactro

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Unit Price : ৳ 10.00
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Lacor

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 130.00
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Lacor

Ad-din Pharmaceuticals Ltd.

Unit Price : ৳ 13.00
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KTM

Silco Pharmaceutical Ltd.

Unit Price : ৳ 10.00
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KTL

Aztec Pharmaceuticals Ltd.

Unit Price : ৳ 8.00
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KPR

Central Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
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Korac

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Unit Price : ৳ 55.00
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Knil

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Knil

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Knil

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
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Kitorex

S.N. Pharmaceutical Ltd.

Unit Price : ৳ 10.00
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Kitocos

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 9.50
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Kilpan

Decent Pharma Laboratories Ltd.

Unit Price : ৳ 10.00
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Kflam

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 95.33
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Kflam

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Kflam

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 11.00
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Kevan

C2C Pharma Ltd.

Unit Price : ৳ 25.00
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Ketromin

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
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Ketromin

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 60.00
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Ketromin

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 80.00
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Ketromin

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 12.00
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Ketoxguard

Guardian Healthcare Ltd.

Unit Price : ৳ 55.00
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Ketoxguard

Guardian Healthcare Ltd.

Unit Price : ৳ 8.00
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Ketovir

Virgo Pharmaceuticals Ltd.

Unit Price : ৳ (20's pack: ৳ 200.00)
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Ketovalor

Mundipharma (BD) Pvt. Ltd.

Unit Price : ৳ 60.00
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Ketostar

Goodman Pharmaceuticals Ltd.

Unit Price : ৳ 11.00
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Ketoshot

Nuvista Pharma Ltd.

Unit Price : ৳ 10.00
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Ketoshot

Nuvista Pharma Ltd.

Unit Price : ৳ 55.00
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Ketoroz

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 55.00
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Ketoroz

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 10.00
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Ketoropack

Marksman Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
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Ketorolac

Pristine Pharmaceuticals Ltd

Unit Price : ৳ 10.00
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Ketorolac

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
🌿
Ketorin

Orion Pharma Ltd.

Unit Price : ৳ 55.16
🌿
Ketorin

Orion Pharma Ltd.

Unit Price : ৳ 10.07
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Ketora

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
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Ketoprix

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 95.29
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Ketoprix

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 55.17
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Keteks

Jenphar Bangladesh Ltd.

Unit Price : ৳ 30.00
🌿
Ketoprix

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 10.03
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Ketoplex

Centeon Pharma Ltd.

Unit Price : ৳ 20.00
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Ketonic

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Ketonic

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Ketonic

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 12.00
🌿
Ketonaaf

Naafco Pharma Ltd.

Unit Price : ৳ 11.00
🌿
Ketolac

Nipa Pharmaceuticals Ltd.

Unit Price : ৳ 80.00
🌿
Ketolac

Nipa Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
🌿
Ketolab

Labaid Pharma Ltd.

Unit Price : ৳ 115.00
🌿
Ketolab

Labaid Pharma Ltd.

Unit Price : ৳ 75.00
🌿
Ketolab

Labaid Pharma Ltd.

Unit Price : ৳ 20.00
🌿
Ketogate

Pharmacil Limited

Unit Price : ৳ 75.23
🌿
Ketoflex

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 10.03
🌿
Ketofenac

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Ketofenac

Doctor TIMS Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
🌿
Ketofast

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 55.16
🌿
Ketofast

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 12.04
🌿
Ketobe

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Ketobe

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 12.00
🌿
Ketoact

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
🌿
Keteks

Jenphar Bangladesh Ltd.

Unit Price : ৳ 95.00
🌿
Keteks

Jenphar Bangladesh Ltd.

Unit Price : ৳ 55.00
🌿
Ket

Delta Pharma Ltd.

Unit Price : ৳ 55.00
🌿
Ket

Delta Pharma Ltd.

Unit Price : ৳ 5.00
🌿
Kerolac

Gaco Pharmaceuticals Ltd.

Unit Price : ৳ 11.00
🌿
Kerol

Premier Pharmaceuticals Ltd.

Unit Price : ৳ 10.00
🌿
Kepros

Monicopharma Ltd.

Unit Price : ৳ 55.00
🌿
Kepros

Monicopharma Ltd.

Unit Price : ৳ 10.00
🌿
Kepronol

Monicopharma Ltd.

Unit Price : ৳ 80.00
🌿
Kenodol

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 95.00
🌿
Kenodol

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 55.00
🌿
Kenodol

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 12.03
🌿
Kelorac

One Pharma Ltd.

Unit Price : ৳ 55.00
🌿
Kelorac

One Pharma Ltd.

Unit Price : ৳ 12.00
🌿
Kelac

Chemist Laboratories Ltd.

Unit Price : ৳ 95.00
🌿
Kelac

Chemist Laboratories Ltd.

Unit Price : ৳ 50.00
🌿
Kelac

Chemist Laboratories Ltd.

Unit Price : ৳ 10.00
🌿
K-Lac

Ethical Drugs Limited

Unit Price : ৳ 10.00
🌿
K-Lac

Ethical Drugs Limited

Unit Price : ৳ 55.00
🌿
K-Lac

Ethical Drugs Limited

Unit Price : ৳ 95.00
🌿
Inket

Indo Bangla Pharmaceutical

Unit Price : ৳ 10.00