Omeprazole is indicated for the treatment of-
* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন
Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.
Due to the decreased intragastric acidity the absorption of ketoconazole may be reduced during omeprazole treatment as it is during treatment with other acid secretion inhibitors. As omeprazole is metabolised in the liver through cytochrome P450 it can delay the elimination of diazepam, phenytoin and warfarin. Monitoring of patients receiving warfarin or pheytoin is recommended and a reduction of warfarin or phenytoin dose may be necessary. However concomitant treatment with omeprazole 20mg daily did not change the blood concentration of phenytoin in patients on continuous treatment with phenytoin. Similarly concomitant treatment with omeprazole 20mg daily did not change coagulation time in patients on continuous treatment with warfarin. Plasma concentrations of omeprazole and clarithromycin are increased during concomitant administration. This is considered to be a useful interaction during H. pylori eardication. There is no evidence of an interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids. The absorption of omeprazole is not affected by alcohol or food. There is no evidence of an interaction with piroxicam, diclofenac or naproxen. This is considered useful when patients are required to continue these treatments. Simultaneous treatment with omeprazole and digoxin in healthy subjects lead to a 10% increase in the bioavailability of digoxin as a consequence of the increased intragastric pH.
Omeprazole is contraindicated in patients with known hypersensitivity to it. When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with omeprazole is instituted, as treatment may alleviate symptoms and delay diagnosis.
Omeprazole is well tolerated and adverse reactions have generally been mild and reversible. Skin rash, urticaria and pruritus have been reported. Usually resolving after discontinuation of treatment. In addition photosensitivity, bullous eruption, erythema multiforme, angioedema and alopecia have been reported in isolated cases. Diarrhoea and headache have been reported and may be severe enough to require discontinuation of therapy in a small number of patients. In the majority of cases the symptoms resolved after discontinuation of therapy. Other gastrointestinal reactions have included constipation, nausea/vomiting, flatulence and abdominal pain. Dry mouth, stomatitis and candidiasis have been reported as isolated cases. Paraesthesia has been reported. Dizziness, light headedness and feeling faint have been associated with treatment, but all usually resolve on cessation of therapy. Also reported are somnolence, insomnia and vertigo. Reversible mental confusion, agitation, depression and hallucinations have occurred predominantly in severely ill patients. Arthritic and myalgic symptoms have been reported and have usually resolved when therapy is stopped. In isolated cases, the following have been reported: blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy in patients with pre-existing severe liver disease, hepatitis with or without jaundice, rarely interstitial nephritis and hepatic failure. Increases in liver enzymes have been observed.
Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy. There is no information available on the passage of Omeprazole into breast milk or its effects on the neonate. Breast-feeding should, therefore, be discontinued, if the use of Omeprazole is considered essential.
Use in Children & Adolescents: Safety and effectiveness of Omeprazole have not been established in pediatric patients less than 18 years of age.
Avoid concomitant use of clopidogrel and omeprazole as the pharmacological activity of clopidogrel is reduced if given concomitantly. Observational studies suggest that proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis- related fractures of the hip, wrist, or spine. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole. Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities.
Proton Pump Inhibitor
Keep in a dry place away from light and heat. Keep out of the reach of children.
Oral-
IV Injection-
Direction for use of IV Injection: Omeprazole lyophilized powder and water for injection is for intravenous administration only and must not be given by any other route. Omeprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute. Use only freshly prepared solution. The solution should be used within 4 hours of reconstitution.
Direction for use of IV Infusion: Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% Dextrose for infusion. The solution should be used within 12 hours when Omeprazole is dissolved in saline and within 6 hours when dissolved in 5% Dextrose. The reconstituted solution should not be mixed or co-administered in the same infusion set with any other drug.
Bengal drugs Ltd.
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Hudson Pharmaceuticals Ltd.
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Hudson Pharmaceuticals Ltd.
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Decent Pharma Laboratories Ltd.
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Apex Pharmaceuticals Ltd.
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Apex Pharmaceuticals Ltd.
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Novo Healthcare and Pharma Ltd.
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Novo Healthcare and Pharma Ltd.
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Pharmasia Limited
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Edruc Limited
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Edruc Limited
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Monicopharma Ltd.
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Monicopharma Ltd.
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Drug International Ltd.
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Drug International Ltd.
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Drug International Ltd.
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Millat Pharmaceuticals Ltd.
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Pharmik Laboratories Ltd.
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Ethical Drugs Limited
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Pharmik Laboratories Ltd.
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Euro Pharma Ltd.
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Euro Pharma Ltd.
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Gonoshasthaya Pharma Ltd.
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Gonoshasthaya Pharma Ltd.
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Euro Pharma Ltd.
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Ethical Drugs Limited
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Biopharma Limited
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Biopharma Limited
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Biopharma Limited
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Delta Pharma Ltd.
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Delta Pharma Ltd.
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Doctor TIMS Pharmaceuticals Ltd.
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Apollo Pharmaceutical Ltd.
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Amico Laboratories Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Aexim Pharmaceuticals Ltd.
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National Drug Co. Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Eskayef Pharmaceuticals Ltd.
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Bristol Pharmaceuticals Ltd.
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Bristol Pharmaceuticals Ltd.
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Everest Pharmaceuticals Ltd.
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Everest Pharmaceuticals Ltd.
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Marksman Pharmaceuticals Ltd.
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FnF Pharmaceuticals Ltd.
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Supreme Pharmaceutical Ltd.
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Nuvista Pharma Ltd.
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Asiatic Laboratories Ltd.
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Asiatic Laboratories Ltd.
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Central Pharmaceuticals Ltd.
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Arges Life Science Limited
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Ambee Pharmaceuticals Ltd.
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Ambee Pharmaceuticals Ltd.
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Rangs Pharmaceuticals Ltd.
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Doctor’s Chemical Works Ltd.
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Somatec Pharmaceuticals Ltd.
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Somatec Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Benham Pharmaceuticals Ltd.
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Benham Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Chemist Laboratories Ltd.
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Chemist Laboratories Ltd.
Unit Price : ৳ 90.00
Novelta Bestway Pharma Ltd.
Unit Price : ৳ 8.03
Centeon Pharma Ltd.
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Centeon Pharma Ltd.
Unit Price : ৳ 8.00
NIPRO JMI Pharma Ltd.
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NIPRO JMI Pharma Ltd.
Unit Price : ৳ 8.02
United Pharmaceuticals Ltd.
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Popular Pharmaceuticals Ltd.
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Popular Pharmaceuticals Ltd.
Unit Price : ৳ 7.03
Popular Pharmaceuticals Ltd.
Unit Price : ৳ 80.00
Goodman Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Goodman Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Medicon Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Medicon Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Amulet Pharmaceuticals Ltd.
Unit Price : ৳ 5.02
Amulet Pharmaceuticals Ltd.
Unit Price : ৳ 7.02
MedRx Life Science Ltd.
Unit Price : ৳ 5.00
MedRx Life Science Ltd.
Unit Price : ৳ 8.00
Naafco Pharma Ltd.
Unit Price : ৳ 5.50
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 6.00
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 10.00
Incepta Pharmaceuticals Ltd.
Unit Price : ৳ 90.00
Jenphar Bangladesh Ltd.
Unit Price : ৳ 90.00
Jenphar Bangladesh Ltd.
Unit Price : ৳ 6.00
Aristopharma Ltd.
Unit Price : ৳ 2.00
Aristopharma Ltd.
Unit Price : ৳ 6.00
Aristopharma Ltd.
Unit Price : ৳ 8.00
Aristopharma Ltd.
Unit Price : ৳ 80.00
Alco Pharma Ltd.
Unit Price : ৳ 4.01
Alco Pharma Ltd.
Unit Price : ৳ 7.02
Ziska Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Ziska Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Ziska Pharmaceuticals Ltd.
Unit Price : ৳ 90.00
Physic pharmaceuticals ltd.
Unit Price : ৳ 5.50
Physic pharmaceuticals ltd.
Unit Price : ৳ 8.50
Silva Pharmaceuticals Ltd.
Unit Price : ৳ 5.75
Pharmadesh Laboratories Ltd.
Unit Price : ৳ 3.50
Silva Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Navana Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Team Pharmaceuticals Ltd.
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Team Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Opsonin Pharma Ltd.
Unit Price : ৳ 6.00
Opsonin Pharma Ltd.
Unit Price : ৳ 7.03
Novus Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Opsonin Pharma Ltd.
Unit Price : ৳ 90.27
Astra Biopharmaceuticals Ltd.
Unit Price : ৳ 4.00
Astra Biopharmaceuticals Ltd.
Unit Price : ৳ 80.00
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 90.00
Virgo Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 5.02
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 5.02
Kemiko Pharmaceuticals Ltd.
Unit Price : ৳ 7.02
Medimet Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Modern Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Guardian Healthcare Ltd.
Unit Price : ৳ 5.02
Kumudini Pharma Ltd.
Unit Price : ৳ 5.00
Quality Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Maks Drug Limited
Unit Price : ৳ 6.00
Jayson Pharmaceutical Ltd.
Unit Price : ৳ 5.50
Jayson Pharmaceutical Ltd.
Unit Price : ৳ 8.02
Gaco Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Nipa Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Nipa Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Allied Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
The White Horse Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Seema Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Ad-din Pharmaceuticals Ltd.
Unit Price : ৳ 5.50
Ad-din Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Techno Drugs Ltd.
Unit Price : ৳ 5.00
Techno Drugs Ltd.
Unit Price : ৳ 7.00
Techno Drugs Ltd.
Unit Price : ৳ 69.68
One Pharma Ltd.
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One Pharma Ltd.
Unit Price : ৳ 9.00
Globe Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Globe Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Healthcare Pharmaceuticals Ltd.
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Healthcare Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Healthcare Pharmaceuticals Ltd.
Unit Price : ৳ 95.00
Globe Pharmaceuticals Ltd.
Unit Price : ৳ 80.00
Zenith Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Zenith Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Concord Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Concord Pharmaceuticals Ltd.
Unit Price : ৳ 6.00
Cosmo Pharma Laboratories Ltd.
Unit Price : ৳ 4.50
Avarox Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Avarox Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Salton Pharmaceuticals Ltd.
Unit Price : ৳ 3.50
MST Pharma
Unit Price : ৳ 4.00
Peoples Pharma Ltd.
Unit Price : ৳ 4.50
Prime Pharmaceuticals Ltd.
Unit Price : ৳ 4.50
Silco Pharmaceutical Ltd.
Unit Price : ৳ 5.00
Silco Pharmaceutical Ltd.
Unit Price : ৳ 8.00
Labaid Pharma Ltd.
Unit Price : ৳ 6.00
Labaid Pharma Ltd.
Unit Price : ৳ 9.03
Leon Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Leon Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Globex Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
ACME Laboratories Ltd.
Unit Price : ৳ 5.01
ACME Laboratories Ltd.
Unit Price : ৳ 9.00
Pacific Pharmaceuticals Ltd.
Unit Price : ৳ 5.50
Renata Limited
Unit Price : ৳ 5.00
Renata Limited
Unit Price : ৳ 90.00
SMC Enterprise Ltd (Mfg. by: Jenphar Bangladesh Ltd.)
Unit Price : ৳ 5.00
SMC Enterprise Ltd
Unit Price : ৳ 7.00
Veritas Pharmaceuticals Ltd.
Unit Price : ৳ 5.01
Veritas Pharmaceuticals Ltd.
Unit Price : ৳ 8.03
Veritas Pharmaceuticals Ltd.
Unit Price : ৳ 4.02
UniMed UniHealth Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
UniMed UniHealth Pharmaceuticals Ltd.
Unit Price : ৳ 7.00
Premier Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
General Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
General Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
General Pharmaceuticals Ltd.
Unit Price : ৳ 80.00
Royal Pharmaceutical Ltd.
Unit Price : ৳ 5.00
Rangs Pharmaceuticals Ltd.
Unit Price : ৳ 5.02
Rangs Pharmaceuticals Ltd.
Unit Price : ৳ 8.03
SANDOZ (A Novartis Division)
Unit Price : ৳ 7.01
SANDOZ (A Novartis Division)
Unit Price : ৳ 10.10
Orion Infusion Ltd.
Unit Price : ৳ 6.00
Orion Infusion Ltd.
Unit Price : ৳ 8.02
Orion Infusion Ltd.
Unit Price : ৳ 90.27
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 100.00
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Beximco Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 5.50
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 9.00
Sharif Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Sharif Pharmaceuticals Ltd.
Unit Price : ৳ 8.03
Ibn Sina Pharmaceuticals Ltd.
Unit Price : ৳ 90.00
Hallmark Pharmaceuticals Ltd.
Unit Price : ৳ 5.01
Hallmark Pharmaceuticals Ltd.
Unit Price : ৳ 7.55
Indo Bangla Pharmaceutical
Unit Price : ৳ 4.00
RN Pharmaceuticals
Unit Price : ৳ 4.50
Oyster Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Reman Drug Laboratories Ltd.
Unit Price : ৳ 5.00
Reman Drug Laboratories Ltd.
Unit Price : ৳ 5.50
Novatek Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Novatek Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Desh Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Desh Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Novatek Pharmaceuticals Ltd.
Unit Price : ৳ 85.00
Rephco Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Reliance Pharmaceuticals Ltd.
Unit Price : ৳ 4.00
Save Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Save Pharmaceuticals Ltd.
Unit Price : ৳ 8.00
Sunman-Birdem Pharma Ltd.
Unit Price : ৳ 8.00
Sunman-Birdem Pharma Ltd.
Unit Price : ৳ 5.00
Square Pharmaceuticals PLC
Unit Price : ৳ 6.00
Square Pharmaceuticals PLC
Unit Price : ৳ 9.00
Square Pharmaceuticals PLC
Unit Price : ৳ 9.00
Biogen Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Biogen Pharmaceuticals Ltd.
Unit Price : ৳ 9.00
Pristine Pharmaceuticals Ltd
Unit Price : ৳ 4.00
Pristine Pharmaceuticals Ltd
Unit Price : ৳ 6.00
Square Pharmaceuticals PLC
Unit Price : ৳ 80.24
Cosmic Pharma Ltd.
Unit Price : ৳ 5.00
Cosmic Pharma Ltd.
Unit Price : ৳ 7.00
Belsen Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Marker Pharma Ltd.
Unit Price : ৳ 4.00
OSL Pharma Limited
Unit Price : ৳ 6.00
Union Pharmaceuticals Ltd
Unit Price : ৳ 6.00
OSL Pharma Limited
Unit Price : ৳ 90.00
Beacon Pharmaceuticals PLC
Unit Price : ৳ 90.27
ACI Limited
Unit Price : ৳ 90.00
ACI Limited
Unit Price : ৳ 3.00
ACI Limited
Unit Price : ৳ 3.00
ACI Limited
Unit Price : ৳ 3.00
ACI Limited
Unit Price : ৳ 6.00
ACI Limited
Unit Price : ৳ 9.00
Beacon Pharmaceuticals PLC
Unit Price : ৳ 5.02
Beacon Pharmaceuticals PLC
Unit Price : ৳ 7.02
Synovia Pharma PLC.
Unit Price : ৳ 8.02
Synovia Pharma PLC.
Unit Price : ৳ 5.02
Beacon Pharmaceuticals PLC
Unit Price : ৳ 5.02
Radiant Pharmaceuticals Ltd.
Unit Price : ৳ 5.02
Radiant Pharmaceuticals Ltd.
Unit Price : ৳ 7.52
Al-Madina Pharmaceuticals Ltd.
Unit Price : ৳ 5.00
Al-Madina Pharmaceuticals Ltd.
Unit Price : ৳ 7.00