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Thiamine Hydrochloride

Indications

Thiamine is specifically used in the treatment of the various manifestations of thiamine deficiency such as Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra. Supplementary Thiamine may be indicated prophylactically in conditions where there is low dietary intake or impaired gastro intestinal absorption of thiamine (e.g. alcohol) or where requirements are increased (pregnancy, carbohydrate rich diet).

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Thiamine Hydrochloride (Vitamin B1) is an essential constituent for the metabolism of carbohydrate and a lot of amino acids. Utilization of pyruvic acid and amino acid in tissue are decreased in Thiamine deficiency. So pyruvic acid and lactic acid are accumulated and cause Beri-beri. In adult, approximately 1 mg of Thiamine per day is completely degraded by the tissues, and this is roughly the minimal daily requirement. Thiamine is well absorbed from the Gastro-intestinal tract and is widely distributed to most body tissues. Excess of the body requirements are excreted in the urine as unchanged or as metabolites.

Dosage & Administration

In the treatment of mild chronic Thiamine deficiency doses up to 30 mg daily in single or divided doses have been recommended. In severe Thiamine deficiency doses up to 300 mg daily have been given.

Interaction

Thiamine has no known severe interactions with other drugs.

Contraindications

Hypersensitivity to Thiamine.

Side Effects

No untoward effects occur when Thiamine is administered orally in amounts many times greater than the therapeutic dose.

Pregnancy & Lactation

The drug may be given safely to neonates, children, pregnant and lactating women and elderly patients.

Precautions & Warnings

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/ tongue/ throat), severe dizziness, trouble breathing.