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Flucloxacillin Sodium

Indications

Flucloxacillin is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by penicillinase producing staphylococci. These indications include:

  • Skin and soft tissue infections: Boils, abscess, carbuncles, infected skin conditions (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).
  • Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy.
  • It is also used for the treatment of other infections i.e. osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia caused by Flucloxacillin-sensitive organisms.
  • As a prophylactic agent, it is used during major surgical procedures where appropriate; for example, cardiothoracic and orthopedic surgery.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Flucloxacillin is active against Gram-positive organisms including penicillinase producing strains. It has little activity against Gram-negative bacilli. Flucloxacillin acts by inhibiting the formation of cell wall of bacteria. Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cellwall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacillin. As a result the bacterial cellwall is weakened, the cell swells and then ruptures. Flucloxacillin resists the action of bacterial penicillinase probably because of the steric hindrance induced by the acyl side chain which prevents the opening of the β- lactam ring.

Interaction

Concurrent use of Flucloxacillin and may result in increased level of Flucloxacillin in blood for prolonged period.

Contraindications

Flucloxacillin is contraindicated in penicillin hypersensitive patients.

Side Effects

There have been some common side effects of gastrointestinal tract such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported.

Pregnancy & Lactation

US FDA Pregnancy Category of Flucloxacillin is B. There are, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Flucloxacillin have been shown to be excreted in human milk. So, caution should be exercised when Flucloxacillin is administered to a lactating mother.

Precautions & Warnings

Flucloxacillin should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with an allergic diathesis.

Therapeutic Class

Penicillinase-resistant penicillins

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Use in Special Populations

In severe renal failure (creatinine clearance <10 ml/min), a reduction in dose or an extension of dose interval should be considered.

Reconstitution

Flucloxacillin has been used in other routes in conjunction with systemic therapy. It has been administered in a dose of 250 mg to 500 mg daily by intraarticular injection, dissolved if necessary in a 0.5% solution of lignocaine hydrochloride, and by intrapleural injection in a dose of 250 mg daily. Using powder for injection, 125 mg-250 mg has been dissolved in 3 ml of sterile water and inhaled by nebuliser four times daily.

Dosage

Oral administration:

  • Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
  • Children (2-10 years): 1/2 of adult dose.
  • Children (Under 2 years): 1/4 of adult dose.

Parenteral administration:
Adult or Elderly:

  • Intramuscular Injection: 250 mg four times daily.
  • Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
  • All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.

Children:

  • 2-10 years: half of the adult dose.
  • Under 2 years: a quarter of the adult dose.

Administration

Oral doses should be administered 1 hour before meal.

Available Brand Names

🌿
A-Flox

ACME Laboratories Ltd.

Unit Price : ৳ 8.00

🌿
A-Flox

ACME Laboratories Ltd.

Unit Price : ৳ 14.00

🌿
A-Flox

ACME Laboratories Ltd.

Unit Price : ৳ 80.00

🌿
A-Flox

ACME Laboratories Ltd.

Unit Price : ৳ 45.30

🌿
Adflox

Team Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

🌿
Ancoc

Marker Pharma Ltd.

Unit Price : ৳ 5.50

🌿
Ancoc

Marker Pharma Ltd.

Unit Price : ৳ 10.00

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Ancoc

Marker Pharma Ltd.

Unit Price : ৳ 60.00

🌿
Auxil

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 5.50

🌿
Auxil

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 9.44

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Auxil

Doctor’s Chemical Works Ltd.

Unit Price : ৳ 55.72

🌿
Bdflox

Bengal drugs Ltd.

Unit Price : ৳ 10.00

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Bdflox

Bengal drugs Ltd.

Unit Price : ৳ 60.00

🌿
Belox

Benham Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Clox-F

Asiatic Laboratories Ltd.

Unit Price : ৳ 5.00

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Clox-F

Asiatic Laboratories Ltd.

Unit Price : ৳ 10.00

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Clox-F

Asiatic Laboratories Ltd.

Unit Price : ৳ 60.00

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Clox-F DS

Asiatic Laboratories Ltd.

Unit Price : ৳ 110.00

🌿
Cloxafu

Sonear Laboratories Ltd.

Unit Price : ৳ 5.64

🌿
Cloxafu

Sonear Laboratories Ltd.

Unit Price : ৳ 10.25

🌿
Cloxakil

Veritas Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

🌿
Debac

FnF Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

🌿
Dolopen

Techno Drugs Ltd.

Unit Price : ৳ 10.00

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Dolopen

Techno Drugs Ltd.

Unit Price : ৳ 60.00

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Dolopen

Techno Drugs Ltd.

Unit Price : ৳ 45.00

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Doribac

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 6.02

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Doribac

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 10.53

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Doribac

Concord Pharmaceuticals Ltd.

Unit Price : ৳ 60.18

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E-Flu

Edruc Limited

Unit Price : ৳ 11.10

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E-Flu

Edruc Limited

Unit Price : ৳ 60.00

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Eflucin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 5.79

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Eflucin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 10.07

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Eflucin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 61.43

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Eflucin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 30.00

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Eflucin

Jayson Pharmaceutical Ltd.

Unit Price : ৳ 40.00

🌿
Enoclox

Modern Pharmaceuticals Ltd.

Unit Price : ৳ 10.54

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Enoclox

Modern Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Faxilin

Kumudini Pharma Ltd.

Unit Price : ৳ 5.50

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Faxilin

Kumudini Pharma Ltd.

Unit Price : ৳ 10.00

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Faxilin

Kumudini Pharma Ltd.

Unit Price : ৳ 60.00

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Flac

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 5.00

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Flac

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Flac

Bristol Pharmaceuticals Ltd.

Unit Price : ৳ 50.00

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Flox

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 5.54

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Flox

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 10.43

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Flox

Hallmark Pharmaceuticals Ltd.

Unit Price : ৳ 60.40

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Flox R

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 6.80

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Flox R

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 12.00

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Flox R

Rangs Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

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Floxabac

OSL Pharma Limited

Unit Price : ৳ 5.88

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Floxabac

OSL Pharma Limited

Unit Price : ৳ 10.50

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Floxabac

OSL Pharma Limited

Unit Price : ৳ 45.30

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Floxapen

General Pharmaceuticals Ltd.

Unit Price : ৳ 6.00

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Floxapen

General Pharmaceuticals Ltd.

Unit Price : ৳ 61.40

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Floxason

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 5.00

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Floxason

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 60.0

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Floxason-DS

Hudson Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Flu-K

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 6.65

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Flu-K

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 10.53

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Flu-K

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 10.53

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Flu-K

Kemiko Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flubac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

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Flubac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 14.00

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Flubac

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 95.00

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Flubac DS

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 110.42

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Flubex

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

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Flubex

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 13.50

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Flubex

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flubex DS

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 110.00

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Flubion

Guardian Healthcare Ltd.

Unit Price : ৳ 10.50

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Flubiotic

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 5.55

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Flubiotic

Navana Pharmaceuticals Ltd.

Unit Price : ৳ 10.05

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Fluc

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Fluc

Astra Biopharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flucil

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 10.00

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Flucil

Cosmo Pharma Laboratories Ltd.

Unit Price : ৳ 60.00

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Flucillin

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

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Flucillin

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Flucillin

Medimet Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flucin

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

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Flucin

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 22.00

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Flucin

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 61.14

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Flucin DS

Millat Pharmaceuticals Ltd.

Unit Price : ৳ 110.00

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Fluclox

ACI Limited

Unit Price : ৳ 8.00

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Fluclox

ACI Limited

Unit Price : ৳ 14.00

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Fluclox

ACI Limited

Unit Price : ৳ 95.00

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Fluclox

ACI Limited

Unit Price : ৳ 55.00

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Fluclox

ACI Limited

Unit Price : ৳ 60.00

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Fluclox DS

ACI Limited

Unit Price : ৳ 135.00

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Flucloxi

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

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Flucloxi

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Flucloxi

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 60.50

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Flucloxin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 5.77

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Flucloxin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

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Flucloxin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

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Flucloxin

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 45.28

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Flucocin

Euro Pharma Ltd.

Unit Price : ৳ 10.52

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Flucopen

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 5.53

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Flucopen

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 10.03

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Flucopen

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 60.23

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Flukin

Pharmasia Limited

Unit Price : ৳ 6.00

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Flukin

Pharmasia Limited

Unit Price : ৳ 11.00

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Flunid

Ethical Drugs Limited

Unit Price : ৳ 5.50

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Flukin

Pharmasia Limited

Unit Price : ৳ 70.00

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Fluking

Chemist Laboratories Ltd.

Unit Price : ৳ 5.50

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Fluking

Chemist Laboratories Ltd.

Unit Price : ৳ 11.00

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Fluking

Chemist Laboratories Ltd.

Unit Price : ৳ 50.00

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Flumark

Aexim Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Flumark

Aexim Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flumed

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

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Flumed

Medicon Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Flunid

Ethical Drugs Limited

Unit Price : ৳ 10.00

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Flunid

Ethical Drugs Limited

Unit Price : ৳ 61.00

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Flupen

Drug International Ltd.

Unit Price : ৳ 5.50

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Flupen

Drug International Ltd.

Unit Price : ৳ 11.50

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Flupen

Drug International Ltd.

Unit Price : ৳ 95.00

🌿
Flurif

Sharif Pharmaceuticals Ltd.

Unit Price : ৳ 10.52

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Flustaph

Orion Pharma Ltd.

Unit Price : ৳ 5.50

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Flustaph

Orion Pharma Ltd.

Unit Price : ৳ 10.00

🌿
Flustaph

Orion Pharma Ltd.

Unit Price : ৳ 59.94

🌿
Flustar

Renata Limited

Unit Price : ৳ 5.50

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Flustar

Renata Limited

Unit Price : ৳ 10.00

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Flustar

Renata Limited

Unit Price : ৳ 60.00

🌿
Flutam

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 5.70

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Flutam

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 6.44

🌿
Flutam DS

Leon Pharmaceuticals Ltd.

Unit Price : ৳ 110.00

🌿
Flutec

APC Pharma Ltd.

Unit Price : ৳ 5.75

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Flutec

APC Pharma Ltd.

Unit Price : ৳ 60.00

🌿
Flutec-DS

APC Pharma Ltd.

Unit Price : ৳ 10.00

🌿
Flux

Opsonin Pharma Ltd.

Unit Price : ৳ 5.77

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Flux

Opsonin Pharma Ltd.

Unit Price : ৳ 11.50

🌿
Flux

Opsonin Pharma Ltd.

Unit Price : ৳ 65.00

🌿
Flux

Opsonin Pharma Ltd.

Unit Price : ৳ 45.30

🌿
Flux

Opsonin Pharma Ltd.

Unit Price : ৳ 25.00

🌿
Flux DS

Opsonin Pharma Ltd.

Unit Price : ৳ 110.75

🌿
Fluxi

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Fluxicap

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 4.60

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Fluxicap

Ziska Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Fluxin

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 58.88

🌿
Fluxin

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 10.04

🌿
Fluxin

Ambee Pharmaceuticals Ltd.

Unit Price : ৳ 5.59

🌿
Flxzen

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 8.00

🌿
Flxzen

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

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Fucil

Nipa Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

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Fucil

Nipa Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

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G-Flucloxacillin

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 7.00

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G-Flucloxacillin

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 25.00

🌿
G-Flucloxacillin

Gonoshasthaya Pharma Ltd.

Unit Price : ৳ 50.00

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Flxzen

Zenith Pharmaceuticals Ltd.

Unit Price : ৳ 5.00

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Halopen

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 5.55

🌿
Halopen

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 10.50

🌿
Halopen

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 65.00

🌿
Inclox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

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Inclox

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Isoclox

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

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Isoclox

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Isoclox

Globe Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

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Isoflu

Central Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

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Isoflu

Central Pharmaceuticals Ltd.

Unit Price : ৳ 60.00

🌿
Luf

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 6.50

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Luf

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 12.00

🌿
Luf

Apex Pharmaceuticals Ltd.

Unit Price : ৳ 80.00

🌿
Monaclox-F

Amico Laboratories Ltd.

Unit Price : ৳ 5.50

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Monaclox-F

Amico Laboratories Ltd.

Unit Price : ৳ 10.00

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Monaclox-F

Amico Laboratories Ltd.

Unit Price : ৳ 65.00

🌿
Murein

One Pharma Ltd.

Unit Price : ৳ 10.50

🌿
Orgaflu

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 5.58

🌿
Orgaflu

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 10.03

🌿
Orgaflu

Novatek Pharmaceuticals Ltd.

Unit Price : ৳ 60.40

🌿
Phylopen

Square Pharmaceuticals PLC

Unit Price : ৳ 8.00

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Phylopen

Square Pharmaceuticals PLC

Unit Price : ৳ 80.00

🌿
Phylopen

Square Pharmaceuticals PLC

Unit Price : ৳ 54.00

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Phylopen DS

Square Pharmaceuticals PLC

Unit Price : ৳ 14.00

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Phylopen Forte

Square Pharmaceuticals PLC

Unit Price : ৳ 125.00

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Revistar

Biopharma Limited

Unit Price : ৳ 6.00

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Revistar

Biopharma Limited

Unit Price : ৳ 10.05

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Revistar

Biopharma Limited

Unit Price : ৳ 60.23

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S-Fluclox

Seema Pharmaceuticals Ltd.

Unit Price : ৳ 7.00

🌿
S-Fluclox

Seema Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

🌿
Silox

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 5.77

🌿
Silox

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 10.04

🌿
Silox

Silva Pharmaceuticals Ltd.

Unit Price : ৳ 60.22

🌿
Sinaflox

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 5.60

🌿
Sinaflox

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 10.50

🌿
Sinaflox

Ibn Sina Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

🌿
Skilox

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 6.00

🌿
Skilox

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

🌿
Skilox

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 65.00

🌿
Sofa

Apollo Pharmaceutical Ltd.

Unit Price : ৳ 5.25

🌿
Sofa

Apollo Pharmaceutical Ltd.

Unit Price : ৳ 60.00

🌿
Softapen

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

🌿
Softapen

Rephco Pharmaceuticals Ltd.

Unit Price : ৳ 70.00

🌿
Staflu

Alco Pharma Ltd.

Unit Price : ৳ 5.79

🌿
Staflu

Alco Pharma Ltd.

Unit Price : ৳ 10.57

🌿
Staflu

Alco Pharma Ltd.

Unit Price : ৳ 65.20

🌿
Staflu DS

Alco Pharma Ltd.

Unit Price : ৳ 110.75

🌿
Stafoxin

Aristopharma Ltd.

Unit Price : ৳ 5.50

🌿
Stafoxin

Aristopharma Ltd.

Unit Price : ৳ 10.00

🌿
Stafoxin

Aristopharma Ltd.

Unit Price : ৳ 60.00

🌿
Staphylox

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 75.00

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Staphylox-500

Pharmadesh Laboratories Ltd.

Unit Price : ৳ 10.50

🌿
Stapkil

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 5.50

🌿
Stapkil

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 10.00

🌿
Stapkil

Pacific Pharmaceuticals Ltd.

Unit Price : ৳ 58.00

🌿
Surgeflox

Cosmic Pharma Ltd.

Unit Price : ৳ 10.29

🌿
Syflu

MST Pharma

Unit Price : ৳ 10.00

🌿
Syflu

MST Pharma

Unit Price : ৳ 61.00

🌿
Topflu

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

🌿
Topflu

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 11.00

🌿
Topflu

Al-Madina Pharmaceuticals Ltd.

Unit Price : ৳ 70.00

🌿
Uflu

Union Pharmaceuticals Ltd

Unit Price : ৳ 5.00

🌿
Uflu

Union Pharmaceuticals Ltd

Unit Price : ৳ 10.00