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Voriconazole

Indications

Voriconazole is an azole antifungal medicine. It is indicated for use in patients 12 years of age and older in the treatment of following fungal infections-

  • Invasive aspergillosis
  • Candidemia (nonneutropenic) and disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds
  • Esophageal candidiasis
  • Serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani
  • Patients intolerant of, or refractory to other therapy.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Voriconazole is a triazole antifungal medication used to treat serious fungal infections. Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.

Dosage & Administration

Oral-
Voriconazole tablet and powder for suspension are to be taken at least one hour before or one hour following a meal

  • At or over 40 kg body weight: Loading dose regimen is 400 mg or 10 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 200 mg or 5 ml twice daily.
  • Below 40 Kg body weight: Loading dose regimen is 200 mg or 5 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 100 mg or 2.5 ml twice daily. Or, as directed by the registered physician.


Injection-
Invasive Aspergillosisd :

  • Loading dose: 6 mg/kg 12 hourly for the first 24 hours.
  • Maintenance Dose: 4 mg/kg 12 hourly.

Candidemia in nonneutropenic patients and other deep tissue Candida infections:

  • Loading dose: 6 mg/kg 12 hourly for the first 24 hours.
  • Maintenance Dose: 3-4 mg/kg 12 hourly.

Scedosporiosis and Fusariosis:

  • Loading dose: 6 mg/kg 12 hourly for the first 24 hours.
  • Maintenance Dose: 4 mg/kg 12 hourly.

Interaction

  • CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers: Adjust Voriconazole dosage and monitor for adverse reactions or lack of efficacy
  • Voriconazole may increase the concentrations and activity of drugs that are CYP3A4, CYP2C9 and CYP2C19 substrates. Reduce doses of these other drugs and monitor for adverse reactions
  • Increase maintenance oral and intravenous dosage of Voriconazole with co-administration of Phenytoin or Efavirenz

Contraindications

Known hypersensitivity to Voriconazole or any other components of this drug-

  • Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions
  • Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids and St. John's Wort due to risk of loss of efficacy

Side Effects

The most common side effects are abdominal pain, anemia, blurred vision, headache, chest pain, nausea and diarrhea.

Pregnancy & Lactation

There are no adequate and well-controlled studies in pregnant woman. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Precautions & Warnings

Long term exposure (treatment or prophylaxis) greater than 180 days requires careful assessment of the benefit-risk balance. Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term voriconazole treatment.

Therapeutic Class

Other Antifungal preparations

Storage Conditions

Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Store Voriconazole powder for suspension between 2° to 8°C temperature.

Use in Special Populations

The efficacy to the children under 12 years of age is not established.

Overdose Effects

There is no data found about overdose of Voriconazole.

Reconstitution

Reconstitution Instructions of suspension: Shake the bottle well before adding water to loosen the powder. Add 25 ml of boiled and cooled water to the bottle (5 spoons of a provided spoon). Shake the closed bottle vigorously until powder mixed completely with the water. Store reconstituted suspension between 15°-30° C. Discard suspension 14 days after reconstitution.

Available Brand Names

🌿
Caspa

Aristopharma Ltd.

Unit Price : ৳ 120.00
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Caspa

Aristopharma Ltd.

Unit Price : ৳ 50.00
🌿
Canvo

Everest Pharmaceuticals Ltd.

Unit Price : ৳ 130.00
🌿
Canvo

Everest Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
🌿
Candicon

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 70.00
🌿
Candicon

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
🌿
Candicon

Popular Pharmaceuticals Ltd.

Unit Price : ৳ 130.00
🌿
Azofend

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
🌿
Azofend

Radiant Pharmaceuticals Ltd.

Unit Price : ৳ 130.00
🌿
Caspa

Aristopharma Ltd.

Unit Price : ৳ 1,000.00
🌿
Vcand

Biopharma Limited

Unit Price : ৳ 1,000.00
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Vcand

Biopharma Limited

Unit Price : ৳ 40.00
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Vcand

Biopharma Limited

Unit Price : ৳ 120.00
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Trivorin

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Trivorin

Somatec Pharmaceuticals Ltd.

Unit Price : ৳ 120.00
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Progil

ACI Limited

Unit Price : ৳ 130.00
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Progil

ACI Limited

Unit Price : ৳ 50.00
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Elazol

Renata Limited

Unit Price : ৳ 50.00
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Elazol

Renata Limited

Unit Price : ৳ 128.00
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Progil

ACI Limited

Unit Price : ৳ 1,000.00
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Viera

Beacon Pharmaceuticals PLC

Unit Price : ৳ 1,000.00
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Vivori

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Vivori

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 70.00
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Vivori

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 1,000.00
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Vivori

Beximco Pharmaceuticals Ltd.

Unit Price : ৳ 100.00
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Viera

Beacon Pharmaceuticals PLC

Unit Price : ৳ 130.00
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Viera

Beacon Pharmaceuticals PLC

Unit Price : ৳ 50.00
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Vicozol

Chemist Laboratories Ltd.

Unit Price : ৳ 100.00
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Vefend

ACME Laboratories Ltd.

Unit Price : ৳ 110.00
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Vefend

ACME Laboratories Ltd.

Unit Price : ৳ 50.00
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Vcent

Pharmasia Limited

Unit Price : ৳ 130.00
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Vcent

Pharmasia Limited

Unit Price : ৳ 50.00
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Voricon

General Pharmaceuticals Ltd.

Unit Price : ৳ 70.00
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Voricon

General Pharmaceuticals Ltd.

Unit Price : ৳ 120.00
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Voricon

General Pharmaceuticals Ltd.

Unit Price : ৳ 1,000.00
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Voricon

General Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Voricare

Delta Pharma Ltd.

Unit Price : ৳ 20.00
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Voricare

Delta Pharma Ltd.

Unit Price : ৳ 50.00
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Voriaid

Labaid Pharma Ltd.

Unit Price : ৳ 50.00
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Voriaid

Labaid Pharma Ltd.

Unit Price : ৳ 130.00
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Vori

Square Pharmaceuticals PLC

Unit Price : ৳ 100.00
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Vori

Square Pharmaceuticals PLC

Unit Price : ৳ 35.00
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Vonazol

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Vonazol

Eskayef Pharmaceuticals Ltd.

Unit Price : ৳ 120.00
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Voriderm

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 2,000.00
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Vorifast

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 2,000.00
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Vorifast

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 1,000.00
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Voriderm

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 1,000.00
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Voriderm

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 110.00
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Voriderm

Incepta Pharmaceuticals Ltd.

Unit Price : ৳ 40.00
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Vorier

One Pharma Ltd.

Unit Price : ৳ 120.00
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Vorier

One Pharma Ltd.

Unit Price : ৳ 35.00
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Vorifast

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 110.00
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Vorifast

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 70.00
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Vorifast

Healthcare Pharmaceuticals Ltd.

Unit Price : ৳ 50.00
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Vorifend

UniMed UniHealth Pharmaceuticals Ltd.

Unit Price : ৳ 130.00
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Vorinox

Opsonin Pharma Ltd.

Unit Price : ৳ 1,000.00
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Vorifix

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 35.00
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Vorifix

NIPRO JMI Pharma Ltd.

Unit Price : ৳ 100.00
🌿
Vorile

Euro Pharma Ltd.

Unit Price : ৳ 45.00
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Vorile

Euro Pharma Ltd.

Unit Price : ৳ 115.00
🌿
Vorinox

Opsonin Pharma Ltd.

Unit Price : ৳ 110.00
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Vorinox

Opsonin Pharma Ltd.

Unit Price : ৳ 50.00
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Vorimart

Desh Pharmaceuticals Ltd.

Unit Price : ৳ 110.00
🌿
Vorile

Euro Pharma Ltd.

Unit Price : ৳ 1,000.00